Synthesis, antibacterial and antifungal activities of electron-rich olefins derived benzimidazole compounds

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dc.authorscopusid6701563510
dc.authorscopusid57195695569
dc.authorscopusid8391965200
dc.authorscopusid6602072580
dc.contributor.authorKüçükbay H.
dc.contributor.authorDurmaz R.
dc.contributor.authorOrhan E.
dc.contributor.authorGünal S.
dc.date.accessioned2024-08-04T19:59:06Z
dc.date.available2024-08-04T19:59:06Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazole derivatives were synthesised by electron-rich olefines (7, 8 and 9) with appropriate reagents. The compounds synthesised were identified by 1H NMR, 13C NMR, FT-IR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the yeasts Candida albicans and Candida tropicalis. Eleven of the compounds inhibited the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC values between 50 and 400 ?g/ml. None of the compounds exhibit antimicrobial activity against Gram-negative bacteria (E. coli and P. Aeruginosa) at the concentrations studied (6.25-800 ?g/ml). Nine of the tested compounds showed an antifungal activity with a range of the MICs between 50 and 400 ?g/ml. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.en_US
dc.description.sponsorshipInönü Üniversitesi: 2000/05en_US
dc.description.sponsorshipWe wish to thank Inönü University (grant no. 2000/05) for financial support for this study.en_US
dc.identifier.doi10.1016/S0014-827X(03)00068-5
dc.identifier.endpage437en_US
dc.identifier.issn0014-827X
dc.identifier.issue6en_US
dc.identifier.pmid12767382en_US
dc.identifier.scopus2-s2.0-0038630972en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.1016/S0014-827X(03)00068-5
dc.identifier.urihttps://hdl.handle.net/11616/90390
dc.identifier.volume58en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofFarmacoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activitiesen_US
dc.subjectAntifungal activitiesen_US
dc.subjectBenzimidazole derivativesen_US
dc.subjectElectron-rich olefinsen_US
dc.subjectIn vitro studiesen_US
dc.titleSynthesis, antibacterial and antifungal activities of electron-rich olefins derived benzimidazole compoundsen_US
dc.typeArticleen_US

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