Cytotoxicity, Radical Scavenging, Antioxidant Properties and Chemical Composition of the Essential Oil of Satureja cilicica P.H. Davis from Turkey

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dc.authoridARABACI, Turan/0000-0003-3869-4557
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridKeleştemur, Ünzile/0000-0003-4531-6378
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authorwosidARABACI, Turan/AAQ-3885-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidKeleştemur, Ünzile/A-4190-2018
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.contributor.authorArabaci, Turan
dc.contributor.authorUzay, Gizem
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:09:51Z
dc.date.available2024-08-04T20:09:51Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSatureja cilicica P. H. Davis is an endemic species of Lamiaceae, distributed in Turkey. In this study, the essential oil of S. cilicica was obtained by hydrodistillation from the aerial parts. The essential oil was analyzed by GC/MS and the main constituents are identified. Radical scavenging capacities of oil obtained from S. cilicica were determined by using DPPH and ABTS radical scavenging assays. In addition, ferric-reducing power of the essential oil was detected. Cytotoxic activity of the essential oil was determined by MTT assay after 24 h treatment of MCF-7. The major components of the essential oil are p-cymene (17.68%), carvacrol (14.02%), gamma-terpinene (11.23 %) and thymol (8.76%). Radical scavenging capacities of the essential oil were measured as 3.28 +/- 0.02 and 238.15 +/- 3.59 mg Trolox equivalent per milliliter of oil in term of DPPH and ABTS radical scavenging, respectively. Ferric-reducing power of essential oil was found 39.76 +/- 3.66 mg Trolox equivalent per milliliter of essential oil. Growth inhibition effect of essential oil against MCF-7 cancer cell is established. According to the results, essential oil of S. cilicica exhibit low cytotoxic activity, with IC50 values, with IC50 value of 268 mu g/mL. The findings of the analyzed species are compared with the results of previous studies.en_US
dc.identifier.doi10.12991/marupj.311814
dc.identifier.endpage505en_US
dc.identifier.issn1309-0801
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85020250355en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage500en_US
dc.identifier.trdizinid302721en_US
dc.identifier.urihttps://doi.org/10.12991/marupj.311814
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/302721
dc.identifier.urihttps://hdl.handle.net/11616/92475
dc.identifier.volume21en_US
dc.identifier.wosWOS:000417368400010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Pharmacyen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectABTSen_US
dc.subjectcytotoxicityen_US
dc.subjectDPPHen_US
dc.subjectessential oil compositionen_US
dc.subjectthymeen_US
dc.titleCytotoxicity, Radical Scavenging, Antioxidant Properties and Chemical Composition of the Essential Oil of Satureja cilicica P.H. Davis from Turkeyen_US
dc.typeArticleen_US

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