The impact of plasma SOCS3 levels and endometrial leukocytes on unexplained infertility

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dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridIlhan, Fulya/0000-0001-7790-1358
dc.authoridOZKAN, ZEHRA SEMA/0000-0001-9185-3663
dc.authorwosiddeveci, şükriye derya/V-9417-2018
dc.authorwosidilhan, fulya N/W-6968-2018
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidOZKAN, ZEHRA SEMA/W-2360-2017
dc.contributor.authorOzkan, Zehra Sema
dc.contributor.authorDeveci, Derya
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorIlhan, Fulya
dc.contributor.authorSimsek, Mehmet
dc.contributor.authorTimurkan, Huseyin
dc.date.accessioned2024-08-04T20:09:56Z
dc.date.available2024-08-04T20:09:56Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: To investigate the possible differences in endometrial leukocyte subtype distribution between women with unexplained infertility and normal fertile women and to determine whether there is a correlation between endometrial leukocyte counts and plasma cytokine levels in unexplained infertility. Materials and methods: This case-control study involved 79 infertile and 40 fertile women. Peripheral venous blood samples and endometrial samples were obtained on day 21 of the menstrual cycle. Plasma interleukin-4 (IL4), IL6, IL10, IL17, IL35, interferongamma (IFN-g), tumor necrosis factor-alpha (TNF-a), transforming growth factor-beta (TGF-b), and suppressor of cytokine signaling-3 (SOCS3) levels were determined by enzyme-linked immunosorbent assay. Endometrial CD8, CD56, and CD163 counts were detected by immunohistochemistry. Results: CD8 and CD56 counts were significantly higher, while CD163 count was significantly lower in infertile women than in fertile women. Plasma SOCS3, IL35, and IL4 levels of the infertile group were significantly lower than those of the fertile group (P < 0.01); the remaining cytokine levels were significantly higher in the infertile group than in the fertile group (P < 0.01). Conclusion: We observed aberrant cytotoxic immune activity in infertile women. The interaction between plasma SOCS3 levels and staining degree of endometrial leukocytes may be either the reason for or result of infertility leading to unavailability of the environment for implantation.en_US
dc.description.sponsorshipFirat University Scientific Research Foundation (FUBAP)en_US
dc.description.sponsorshipThis study was financially supported by Firat University Scientific Research Foundation (FUBAP).en_US
dc.identifier.doi10.3906/sag-1707-103
dc.identifier.endpage516en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid29914245en_US
dc.identifier.scopus2-s2.0-85048625009en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage509en_US
dc.identifier.trdizinid323434en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1707-103
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/323434
dc.identifier.urihttps://hdl.handle.net/11616/92499
dc.identifier.volume48en_US
dc.identifier.wosWOS:000435653900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCD56en_US
dc.subjectCD163en_US
dc.subjectCD8en_US
dc.subjectunexplained infertilityen_US
dc.subjectSOCS3en_US
dc.titleThe impact of plasma SOCS3 levels and endometrial leukocytes on unexplained infertilityen_US
dc.typeArticleen_US

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