The Effects of Stereotactic Cerebroventricular Administration of Albumin, Mannitol, Hypertonic Sodium Chloride, Glycerin and Dextran in Rats with Experimental Brain Edema

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAkyuva, Yener/0000-0001-8171-5929
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidMenekse, Guner/S-5325-2016
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAkyuva, Yener/AAV-5706-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorAtes, Tuncay
dc.contributor.authorGezercan, Yurdal
dc.contributor.authorMenekse, Guner
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOkten, Ali Ihsan
dc.contributor.authorAkyuva, Yener
dc.date.accessioned2024-08-04T20:09:52Z
dc.date.available2024-08-04T20:09:52Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAIM: To evaluate the effects of cerebroventricular administration of hyperoncotic/hyperosmotic agents on edematous brain tissue in rats with experimental head trauma. MATERIAL AND METHODS: The study included 54 female Sprague-Dawley rats with weights ranging between 200 and 250 g. Six experimental groups were examined with each group containing 9 rats. All rats were exposed to head trauma, and treatment groups were administered 2 mu l of one of the drugs (albumin, mannitol, hypertonic sodium chloride (NaCl), glycerin and dextran) 6, 12 and 24 hours after the trauma via the cerebroventricular route and using a stereotactic device. Rats were sacrificed 48 hours after the trauma, and brain tissues were extracted without damage. Biochemical analyses including reduced glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 beta (IL-1 beta) were performed on the injured left hemisphere. RESULTS: Compared with the control group, the albumin, mannitol, 3% NaCl and glycerin treatment groups revealed dramatic increases in GSH levels (p < 0.001). Levels of MDA, which is the end-product of brain edema and lipid peroxidation, failed to show a statistically significant decrease, but there was a decreasing trend observed in the inter-group comparisons. NO levels were also decreased in the 3% NaCl treatment group. An analysis of TNF-alpha and IL-1 beta, two proinflammatory cytokines associated with the trauma, revealed that IL-1 beta decreased significantly in all treatment groups (p=0.001), whereas no significant difference was detected in TNF-alpha levels. CONCLUSION: Cerebroventricular administration of hyperoncotic/hyperosmotic agents provides substantial effects on the treatment of brain edema.en_US
dc.identifier.doi10.5137/1019-5149.JTN.17231-16.1
dc.identifier.endpage923en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid27593830en_US
dc.identifier.scopus2-s2.0-85032579078en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage917en_US
dc.identifier.trdizinid273505en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.17231-16.1
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/273505
dc.identifier.urihttps://hdl.handle.net/11616/92483
dc.identifier.volume27en_US
dc.identifier.wosWOS:000417623700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbuminen_US
dc.subjectBrain edemaen_US
dc.subjectCerebroventricular administrationen_US
dc.subjectDextranen_US
dc.subjectGlycerinen_US
dc.subjectHead traumaen_US
dc.subjectMannitolen_US
dc.subjectNaClen_US
dc.titleThe Effects of Stereotactic Cerebroventricular Administration of Albumin, Mannitol, Hypertonic Sodium Chloride, Glycerin and Dextran in Rats with Experimental Brain Edemaen_US
dc.typeArticleen_US

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