Pd-N-heterocyclic carbene complex catalysed C-H bond activation of 2-isobutylthiazole at the C5 position with aryl bromides
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Soc Chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An effective and efficient catalytic system has been reported for the synthesis of C5-arylated 2-isobutylthiazoles. Pd-N-heterocyclic carbene complexes like [Pd(mu-Cl)Cl(SIPr)](2) (2) and (LCl2Pd-SIPr) (3: L = PPh3, 4: L = Py; 5: L = 3-CHO-Py) were synthesized and characterized by H-1, C-13, P-31 NMR, LC-MS/MS, elemental analysis, and FTIR spectroscopy. These Pd-N-heterocyclic carbene complexes were assessed for the first time as catalysts for the C-H arylation reaction of 2-isobutylthiazole at the C5 position with different (hetero)aryl bromides. The catalytic system showed a low catalyst loading (1 mol%) and did not require the use of additional additives such as pivalic acid. The catalytic system developed with these catalysts enables the synthesis of fine chemicals in high yields under aerobic or anaerobic conditions. All complexes showed moderate to good yields in the C5 direct arylation of 2-isobutylthiazole, while complex 2 exhibited higher catalytic activity than the other complexes.
Açıklama
Anahtar Kelimeler
Direct Arylation, Thiazole Derivatives, Palladium Complexes, Heteroarenes, (Hetero)Arylation, 5-Position
Kaynak
New Journal of Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
45
Sayı
14
