Pd-N-heterocyclic carbene complex catalysed C-H bond activation of 2-isobutylthiazole at the C5 position with aryl bromides

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dc.authoridBugday, Nesrin/0000-0002-3882-035X
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authoridKhan, Siraj/0000-0003-1948-452X
dc.authoridyasar, sedat/0000-0001-7285-2761
dc.contributor.authorKhan, Siraj
dc.contributor.authorBugday, Nesrin
dc.contributor.authorYasar, Sedat
dc.contributor.authorUllah, Naseem
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:49:27Z
dc.date.available2024-08-04T20:49:27Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAn effective and efficient catalytic system has been reported for the synthesis of C5-arylated 2-isobutylthiazoles. Pd-N-heterocyclic carbene complexes like [Pd(mu-Cl)Cl(SIPr)](2) (2) and (LCl2Pd-SIPr) (3: L = PPh3, 4: L = Py; 5: L = 3-CHO-Py) were synthesized and characterized by H-1, C-13, P-31 NMR, LC-MS/MS, elemental analysis, and FTIR spectroscopy. These Pd-N-heterocyclic carbene complexes were assessed for the first time as catalysts for the C-H arylation reaction of 2-isobutylthiazole at the C5 position with different (hetero)aryl bromides. The catalytic system showed a low catalyst loading (1 mol%) and did not require the use of additional additives such as pivalic acid. The catalytic system developed with these catalysts enables the synthesis of fine chemicals in high yields under aerobic or anaerobic conditions. All complexes showed moderate to good yields in the C5 direct arylation of 2-isobutylthiazole, while complex 2 exhibited higher catalytic activity than the other complexes.en_US
dc.description.sponsorshipInonu University (BAP Project) [FBG-2019-1789]en_US
dc.description.sponsorshipThis work was supported by the Inonu University (BAP Project No: FBG-2019-1789) and we would like to thank the Turkiye Burslar for grand S. Khan.en_US
dc.identifier.doi10.1039/d1nj00514f
dc.identifier.endpage6292en_US
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue14en_US
dc.identifier.scopus2-s2.0-85104025268en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6281en_US
dc.identifier.urihttps://doi.org/10.1039/d1nj00514f
dc.identifier.urihttps://hdl.handle.net/11616/99876
dc.identifier.volume45en_US
dc.identifier.wosWOS:000631740000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNew Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDirect Arylationen_US
dc.subjectThiazole Derivativesen_US
dc.subjectPalladium Complexesen_US
dc.subjectHeteroarenesen_US
dc.subject(Hetero)Arylationen_US
dc.subject5-Positionen_US
dc.titlePd-N-heterocyclic carbene complex catalysed C-H bond activation of 2-isobutylthiazole at the C5 position with aryl bromidesen_US
dc.typeArticleen_US

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