Learning of serial digits leads to frontal activation in functional MR imaging

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dc.authorscopusid6603854521
dc.authorscopusid55945937900
dc.contributor.authorKarakaş H.M.
dc.contributor.authorKarakaş S.
dc.date.accessioned2024-08-04T20:02:11Z
dc.date.available2024-08-04T20:02:11Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Clinical studies have shown that performance on the serial digit learning test (SDLT) is dependent upon the mesial temporal lobes, which are responsible for learning and its consolidation. However, an effective SDLT performance is also dependent upon sequencing, temporal ordering, and the utilization of mnemonic strategies. All of these processes are among the functions of the frontal lobes, in spite of this, the relationship between SDLT performance and the frontal lobes has not been demonstrated with previously used mapping techniques. The aim of this study was to investigate the areas of the brain that are activated by SDLT performance. Materials and methods: Ten healthy, eight handed volunteers (mean age, 20.1 years; SD: 3.3) who had 12 years of education were studied with a 1.0 T MR imaging scanner. BOLD (blood oxygen level dependent) contrast and a modified SDLT were used. Activated loci were automatically mapped using a proportional grid. Results: In learning, the most consistent activation was observed in B-a-7 of the right (80%) and the left hemispheres (50%). In recall, the most consistent activation was observed in B-a-7 of the eight hemisphere (60%). Activations were observed in 2.5±0.97 Talairach volumes in learning, whereas they encompassed 1.7±0.95 volumes in recall. The difference between both phases (learning and recall) regarding total activated volume was significant (p<0.05). Conclusion: The prefrontal activation during SDLT performance was not related to learning or to recall, but to a function that is common to both of these cognitive processes. A candidate for this common factor may be the executive functions, which also include serial position processing and temporal ordering. © Turkish Society of Radiology 2006.en_US
dc.identifier.endpage13en_US
dc.identifier.issn1305-3825
dc.identifier.issue1en_US
dc.identifier.pmid16538577en_US
dc.identifier.scopus2-s2.0-33644929685en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/11616/91483
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFrontal lobeen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.subjectPrefrontal areaen_US
dc.subjectSequencingen_US
dc.subjectSerial digit learning testen_US
dc.subjectTemporal orderingen_US
dc.titleLearning of serial digits leads to frontal activation in functional MR imagingen_US
dc.typeArticleen_US

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