Evaluation of MMP-9, MMP-13, MMP-21, and TIMP-1 expressions in malign melanom, dysplastic nevi, and banal nevi

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dc.authoridGirgin, Rabia Burcin/0000-0003-4124-6261
dc.authorwosidGirgin, Rabia Burcin/AAQ-1142-2021
dc.contributor.authorYuvruk, Meryem
dc.contributor.authorGirgin, Rabia Burcin
dc.contributor.authorZemheri, Ebru
dc.date.accessioned2024-08-04T20:10:25Z
dc.date.available2024-08-04T20:10:25Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Although the role of MMPs in the pathogenesis of melanoma is known, few studies have investigated their role in the development of nevi and dysplastic nevi. This study aims to search the expression differences of MMP-9, MMP-13, MMP-21, and TIMP-1 between malignant melanoma (MM), intradermal nevi (IDN), and dysplastic nevi (DN). METHODS: MMP-9, MMP-13, MMP-21, and TIMP-1 antibodies were studied immunohistochemically for 60 cases in our pathology clinic archive between 2013 and 2014. RESULTS: The MM group had the highest expression percentage and intensity for MMP-9 (p<0.001). There was no statistical significance between MMP-13 expression intensities of lesion cells and stromal cells and stromal expression intensities (p>0.05). MMP-21 lesion staining intensities in DN and MM compared to IDN were statistically significant (p=0.001, p=0.011, respectively). For TIMP-1, there was a significant difference between the IDN and the MM group regarding the staining proportion of lesion cells (p<0.01). There was a statistically significant difference in all groups according to lesion cells' expression intensity. (IDN-DN p<0.001, IDN-MM p=0.044, DN-MM p<0.001). CONCLUSION: The following markers can be helpful when lesions cannot be differentiated; increased staining proportions and intensity of MMP-9 in both lesion and stromal cells favor MM in cases where MM and IDN cannot be differentiated. The increased MMP-13 staining proportion of lesion cells can favor DN in cases where the pathologist cannot differentiate DN and MM. Intense expression of MMP-21 by lesion cells can be a potential marker for evaluating the lesion in favor of DN in cases where DN and IDN cannot be differentiated. The high expression intensity of TIMP-1 in lesion cells can favor DN in cases where there is ambiguity between DN and MM. High expression proportion and intensity of stromal cells of TIMP-1 can be useable in favor of MM in cases where MM and DN cannot be differentiated.en_US
dc.description.sponsorshipScientific Research Projects Commission of Istanbul Medeniyet University [TTU-2015-653]en_US
dc.description.sponsorshipThe Scientific Research Projects Commission of Istanbul Medeniyet University [TTU-2015-653].en_US
dc.identifier.doi10.14744/nci.2023.69009
dc.identifier.endpage166en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue2en_US
dc.identifier.pmid38757103en_US
dc.identifier.scopus2-s2.0-85193235570en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage158en_US
dc.identifier.trdizinid1242352en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2023.69009
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1242352
dc.identifier.urihttps://hdl.handle.net/11616/92773
dc.identifier.volume11en_US
dc.identifier.wosWOS:001216103300008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDysplastic nevusen_US
dc.subjectintradermal nevusen_US
dc.subjectmalignant melanomaen_US
dc.subjectMMPen_US
dc.subjectTIMP-1en_US
dc.titleEvaluation of MMP-9, MMP-13, MMP-21, and TIMP-1 expressions in malign melanom, dysplastic nevi, and banal nevien_US
dc.typeArticleen_US

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