The effects of phenoxybenzamine on tyrosine hydroxylase (TH) and TH mRNA level in adrenal medulla of sprague dawley rats

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dc.authorscopusid6602072091
dc.contributor.authorYurekli M.
dc.date.accessioned2024-08-04T20:00:53Z
dc.date.available2024-08-04T20:00:53Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of anti-hipertensive phenoxybenzamine were investigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were used. Phenoxybenzamine was injected i.p. as 20 mg/kg which prepared in the 0.9% NaCl and 5% ethanole. TH activity was measured by detecting of formation of 3H2O as a formation of dopa from 3H-tyrosine by radioisotope technique total adrenal RNA was isolated and hybridized with 32P labeled cDNA. TH mRNA was assayed by densitometric scanning of the autoradiograms using a densitometer. TH activity and TH mRNA levels were found to be significantly increased by the effect of phenoxybenzamine (P<0.01).en_US
dc.identifier.endpage39en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0031867850en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://hdl.handle.net/11616/91079
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenal medullaen_US
dc.subjectPhenoxybenzamineen_US
dc.subjectTH mRNAen_US
dc.subjectTyrosine hydroxylaseen_US
dc.titleThe effects of phenoxybenzamine on tyrosine hydroxylase (TH) and TH mRNA level in adrenal medulla of sprague dawley ratsen_US
dc.typeArticleen_US

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