Evaluation of Teratogenic and Developmental Toxicity of Diclofenac Sodium on Zebrafish (Danio rerio) Larvae
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kahramanmaras Sutcu Imam Univ Rektorlugu
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, the effects of diclofenac sodium (DKFS), used in medicine and veterinary medicine to control pain and inflammation, on zebrafish embryos and larvae were evaluated. Embryos were exposed to 0.21-5.33 mg L-1 DCFS for 96 hours and the survival rates, heart rate, hatching rates and body malformations of these individuals were determined. LC50, EC50 and teratogenic index (TI) values were calculated as 1.55 and 0.81, 1.91, respectively. DKFS is teratogenic for zebrafish embryos based on the calculated TI value. DKFS at concentrations of 0.47 mg L-1 and higher caused pericardial edema, yolk sac edema, tail malformation and spinal curvature in zebrafish. The most common malformations were determined as pericardial and yolk sac edema. At concentrations of 0.7 mg L-1 and higher, it caused significant inhibition in the length and heart rate of zebrafish larvae. It has been shown that DKFS at concentrations of 2.37 mg L-1 and higher reduced the hatching rate of zebrafish below 50%. These results show that DKFS causes adverse effects on zebrafish development and may adversely affect the aquatic ecosystem if it enters the aquatic environment.
Açıklama
Anahtar Kelimeler
Diclofenac sodium, Zebrafish embryo test, Toxicity
Kaynak
Ksu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Nature
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
26
Sayı
1
