Evaluation of Teratogenic and Developmental Toxicity of Diclofenac Sodium on Zebrafish (Danio rerio) Larvae

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dc.authoridturhan, duygu ozhan/0000-0002-7111-4289
dc.authorwosidturhan, duygu ozhan/AAA-3247-2021
dc.contributor.authorTurhan, Duygu Ozhan
dc.date.accessioned2024-08-04T20:11:41Z
dc.date.available2024-08-04T20:11:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the effects of diclofenac sodium (DKFS), used in medicine and veterinary medicine to control pain and inflammation, on zebrafish embryos and larvae were evaluated. Embryos were exposed to 0.21-5.33 mg L-1 DCFS for 96 hours and the survival rates, heart rate, hatching rates and body malformations of these individuals were determined. LC50, EC50 and teratogenic index (TI) values were calculated as 1.55 and 0.81, 1.91, respectively. DKFS is teratogenic for zebrafish embryos based on the calculated TI value. DKFS at concentrations of 0.47 mg L-1 and higher caused pericardial edema, yolk sac edema, tail malformation and spinal curvature in zebrafish. The most common malformations were determined as pericardial and yolk sac edema. At concentrations of 0.7 mg L-1 and higher, it caused significant inhibition in the length and heart rate of zebrafish larvae. It has been shown that DKFS at concentrations of 2.37 mg L-1 and higher reduced the hatching rate of zebrafish below 50%. These results show that DKFS causes adverse effects on zebrafish development and may adversely affect the aquatic ecosystem if it enters the aquatic environment.en_US
dc.identifier.doi10.18016/ksutarimdoga.vi.1028753
dc.identifier.endpage191en_US
dc.identifier.issn2619-9149
dc.identifier.issue1en_US
dc.identifier.startpage183en_US
dc.identifier.trdizinid1159340en_US
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.1028753
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1159340
dc.identifier.urihttps://hdl.handle.net/11616/92905
dc.identifier.volume26en_US
dc.identifier.wosWOS:000933728300021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKahramanmaras Sutcu Imam Univ Rektorluguen_US
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Natureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiclofenac sodiumen_US
dc.subjectZebrafish embryo testen_US
dc.subjectToxicityen_US
dc.titleEvaluation of Teratogenic and Developmental Toxicity of Diclofenac Sodium on Zebrafish (Danio rerio) Larvaeen_US
dc.typeArticleen_US

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