Evaluation of systemic tissue involvement in mice following intraperitoneal inoculation of Toxoplasma gondii RH Ankara strain

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dc.contributor.authorŞamdancı Türkmen, Emine
dc.contributor.authorTaylan Özkan, Ayşegül
dc.contributor.authorBabür, Cahit
dc.contributor.authorMungan, Mesut
dc.contributor.authorAydın, Engin
dc.date.accessioned2020-06-01T08:56:03Z
dc.date.available2020-06-01T08:56:03Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.descriptionTurk Hijyen ve Deneysel Biyoloji Dergisi Volume 72, Issue 1, 2015, Pages 27-36en_US
dc.description.abstractObjective: This study aimed to pathologically evaluate systemic tissue involvement in acute toxoplasmosis in mice inoculated with Toxoplasma gondii RH Ankara strain. Method: Forty-two Mus musculus albino mice were divided into four groups with the control group receiving no inoculation, the group consisting of mice that were not sacrificed after intraperitoneal inoculation and the groups consisting of mice euthanasia were performed on day runner up or day fourth following intraperitoneal inoculation. A 48-50-hour intraperitoneal passage of T. gondii RH Ankara strain in mice was used for inoculation and each mouse received 5×104 tachyzoites. The mice sacrificed by euthanasia were macroscopically examined and then collected tissue samples fixed in 10% formalin. The preparations set by from the tissues blocked in paraffin were stained with hematoxylin-eosin and histopathological examination was performed. Results: Necrosis in the serosa of the intestine and parenchyma of the liver, spleen, kidneys, pancreases and omentum and many free groups of tachyzoites were observed. Tachyzoites were identified in alveolar capillary lumens in the lungs. No pathological finding was observed in the cerebrum and cerebellum but few tachyzoites. It was observed that tissue necrosis and the density of Toxoplasma gondii tachyzoites were directly proportional to the duration of post inoculation. All infected mice that received no intervention died on day sixth. In this study in mice, it was found that T. gondii RH Ankara strain induced the same pathological findings as the RH strain belonging to the virulent Type I group. Conclusion: Mice inoculation can be used for diagnosis and this model may also be used in studies investigating vaccination, drugs and pathogenesis.en_US
dc.identifier.citationŞamdanci Türkmen, E., Taylan Özkan, A., Babür, C., Mungan, M., Aydin, E. Evaluation of systemic tissue involvement in mice following intraperitoneal inoculation of Toxoplasma gondii RH Ankara strain. (2015). Turk Hijyen ve Deneysel Biyoloji Dergisi.en_US
dc.identifier.doi10.5505/TurkHijyen.2015.32448en_US
dc.identifier.endpage36en_US
dc.identifier.issn0377-9777
dc.identifier.issn1308-2523
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84928386473en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage27en_US
dc.identifier.trdizinid171461en_US
dc.identifier.urihttps://doi.org/10.5505/TurkHijyen.2015.32448
dc.identifier.urihttps://hdl.handle.net/11616/15613
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/171461
dc.identifier.volume72en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRefik Saydam National Public Health Agency (RSNPHA)en_US
dc.relation.ispartofTürk Hijyen ve Deneysel Biyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectTransforming growthen_US
dc.subjectSerotoninen_US
dc.titleEvaluation of systemic tissue involvement in mice following intraperitoneal inoculation of Toxoplasma gondii RH Ankara strainen_US
dc.typeArticleen_US

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