Design of starch functionalized biodegradable P(MAA-co-MMA) as carrier matrix for L-asparaginase immobilization

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.contributor.authorUlu, Ahmet
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:42:35Z
dc.date.available2024-08-04T20:42:35Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe prepared biodegradable P(MAA-co-MMA)-starch composite as carrier matrix for the immobilization of L-asparaginase (L-ASNase), an important chemotherapeutic agent in acute lymphoblastic leukemia. Chemical characteristics and thermal stability of the prepared composites were determined by FT-IR, TGA, DTA and, DSC, respectively. Also, biodegradability measurements of P(MAA-co-MMA)-starch composites were carried out to examine the effects of degradation of the starch. Then, L-ASNase was immobilized on the P(MAA-co-MMA)-starch composites. The surface morphology of the composite before and after immobilization was characterized by SEM, EDX, and AFM. The properties of the immobilized L-ASNase were investigated and compared with the free enzyme. The immobilized L-ASNase had better showed thermal and pH stability, and remained stable after 30 days of storage at 25 degrees C. Thus, based on the findings of the present work, the P(MAA-co-MMA)-starch composite can be exploited as the biocompatible matrix used for L-ASNase immobilization for medical applications due to biocompatibility and biodegradability. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University [BAP 2013/37]en_US
dc.description.sponsorshipThe authors thank the financial support from The Inonu University Scientific Research Projects Unit by grant BAP 2013/37.en_US
dc.identifier.doi10.1016/j.carbpol.2016.08.019
dc.identifier.endpage572en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid27561529en_US
dc.identifier.scopus2-s2.0-84982924444en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2016.08.019
dc.identifier.urihttps://hdl.handle.net/11616/97472
dc.identifier.volume153en_US
dc.identifier.wosWOS:000382317200065en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-Asparaginaseen_US
dc.subjectEnzyme immobilizationen_US
dc.subjectP(MAA-co-MMA)en_US
dc.subjectStarchen_US
dc.subjectBiocompositeen_US
dc.titleDesign of starch functionalized biodegradable P(MAA-co-MMA) as carrier matrix for L-asparaginase immobilizationen_US
dc.typeArticleen_US

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