The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

Küçük Resim Yok

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Sage Publications Ltd

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group (p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters (p > 0.05) in the patient group. All biomarkers were positively correlated with each other (p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

Açıklama

Anahtar Kelimeler

Asbestos, malign pleural mesothelioma, YKL-40, tenascin-C, IDO, neopterin, periostin

Kaynak

Human & Experimental Toxicology

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

40

Sayı

11

Künye