The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

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dc.authoridunuvar, songul/0000-0001-8454-490X
dc.contributor.authorTanriverdi, Zubeyde
dc.contributor.authorMeteroglu, Fatih
dc.contributor.authorYuce, Hande
dc.contributor.authorSenyigit, Abdurrahman
dc.contributor.authorIscan, Mumtaz
dc.contributor.authorUnuvar, Songul
dc.date.accessioned2024-08-04T20:50:14Z
dc.date.available2024-08-04T20:50:14Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group (p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters (p > 0.05) in the patient group. All biomarkers were positively correlated with each other (p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [TDK-2019/1512]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Inonu University Department of Scientific Research Projects (Project Number: TDK-2019/1512).en_US
dc.identifier.doi10.1177/09603271211017324
dc.identifier.endpage1824en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue11en_US
dc.identifier.pmid33998299en_US
dc.identifier.scopus2-s2.0-85105944105en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1817en_US
dc.identifier.urihttps://doi.org/10.1177/09603271211017324
dc.identifier.urihttps://hdl.handle.net/11616/99929
dc.identifier.volume40en_US
dc.identifier.wosWOS:000652298600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsbestosen_US
dc.subjectmalign pleural mesotheliomaen_US
dc.subjectYKL-40en_US
dc.subjecttenascin-Cen_US
dc.subjectIDOen_US
dc.subjectneopterinen_US
dc.subjectperiostinen_US
dc.titleThe usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesotheliomaen_US
dc.typeArticleen_US

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