Altered adrenomedullin levels of the rats exposed to constant darkness and light stress
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Although a variety of physiological and psychological stressors stimulate a significant increase in adrenomedullin (ADM) levels, suggesting a regulatory or protective role for ADM in countering the hypothalamo-pituitary-adrenal (HPA) axis activation following these stressors, it is still unknown whether light or darkness stress is involved in the endogenous ADM production systems. This study is aimed to investigate the effects of constant light or darkness for 60 days on ADM level in the plasma of adult male rats. ADM concentrations were assessed before and after the stressors in tail arterial blood by using HPLC. In the both groups, ADM levels greatly increased in the first week and than continued with lesser changes from the control levels. In conclusion, the study showed that keeping the rats in constant darkness and light vicinity for a long time altered ADM synthesis and secretion from the plasma or other tissues. (C) 2008 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
adrenomedullin, constant darkness, light, stress, rat, HPLC
Kaynak
Journal of Photochemistry and Photobiology B-Biology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
91
Sayı
1
