Altered adrenomedullin levels of the rats exposed to constant darkness and light stress

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dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorYuksel, Sengul
dc.date.accessioned2024-08-04T20:30:47Z
dc.date.available2024-08-04T20:30:47Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough a variety of physiological and psychological stressors stimulate a significant increase in adrenomedullin (ADM) levels, suggesting a regulatory or protective role for ADM in countering the hypothalamo-pituitary-adrenal (HPA) axis activation following these stressors, it is still unknown whether light or darkness stress is involved in the endogenous ADM production systems. This study is aimed to investigate the effects of constant light or darkness for 60 days on ADM level in the plasma of adult male rats. ADM concentrations were assessed before and after the stressors in tail arterial blood by using HPLC. In the both groups, ADM levels greatly increased in the first week and than continued with lesser changes from the control levels. In conclusion, the study showed that keeping the rats in constant darkness and light vicinity for a long time altered ADM synthesis and secretion from the plasma or other tissues. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jphotobiol.2008.01.007
dc.identifier.endpage23en_US
dc.identifier.issn1011-1344
dc.identifier.issue1en_US
dc.identifier.pmid18316198en_US
dc.identifier.scopus2-s2.0-41849149371en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2008.01.007
dc.identifier.urihttps://hdl.handle.net/11616/94505
dc.identifier.volume91en_US
dc.identifier.wosWOS:000255569200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Photochemistry and Photobiology B-Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectconstant darknessen_US
dc.subjectlighten_US
dc.subjectstressen_US
dc.subjectraten_US
dc.subjectHPLCen_US
dc.titleAltered adrenomedullin levels of the rats exposed to constant darkness and light stressen_US
dc.typeArticleen_US

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