Daptomycin in combination with rosuvastatin induced blood creatine phosphokinase elevation
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmj Publishing Group
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We present the case of a 73-year-old male patient who was hospitalised with infective endocarditis, and report an elevation in his blood creatine phosphokinase (CPK) after receiving daptomycin and rosuvastatin therapy concomitantly. His previous home-scheduled medications included apixaban, ivabradine, metformin, rosuvastatin 20 mg, ginkgo biloba and trimetazidine, and he continued to receive these medications at the hospital. After three sets of blood cultures were taken, empirical treatment was started with vancomycin and gentamicin. On the eighth day of treatment, daptomycin and ampicillin-sulbactam were initiated due to ampicillin-resistant Enterococcus faecalis growth in the patient's blood culture. Daptomycin and rosuvastatin were discontinued on the 23rd day of treatment because of blood CPK elevation (2416 U/L) and linezolid was started instead of daptomycin. Six days after discontinuation of daptomycin and rosuvastatin, the CPK concentrations returned to normal range.
Açıklama
Anahtar Kelimeler
clinical pharmacy, cardiology, infection control, side effects of drugs, case report
Kaynak
European Journal of Hospital Pharmacy
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
28
Sayı
4
