The effect of trimethazidine on mortality in an experimental acute pancreatitis model

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dc.authoridiflazoğlu, nidal/0000-0001-7727-602X;
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidiflazoğlu, nidal/H-4080-2015
dc.authorwosidSARAÇ, Mehmet/W-7817-2018
dc.contributor.authorErgucuk, Hakan
dc.contributor.authorIsik, Sevil
dc.contributor.authorIflazoglu, Nidal
dc.contributor.authorKayaalp, Cuneyt
dc.contributor.authorSarac, Mehmet
dc.contributor.authorGursul, Serdar
dc.date.accessioned2024-08-04T20:10:01Z
dc.date.available2024-08-04T20:10:01Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: Acute pancreatitis has a high morbidty and mortality. Its physiopathogenesis has not been enlightened up to the present. This study aims to investigate trimethazidine (antiischemic, antioxidant and cardioprotective agent) 's effects on the acute pancreatitis. Materials-Methods: In this study, four aqual groups are formed with 43 female Spraque-dawley type rats weighed between 230-300 gr (mean 265 gr). 0.9% NaCl is injected intraperitoneally after laparotomy to the Group 1 (n=6). Group 2 (n=6) is control group that without any intervention. Acute pancreatitis is formed in Group 3 (n=16) via injection of Na-taurocholate in the common bile duct. Group 4 (n=15) is being formed pancreatitis and treated with Trimetazidine. In group 4 Trimetazidine 10 mg/kg/day drugs were given, 30 minutes, 24 and 72 hours after formation of acute pancreatitis, in three equal doses by orogastric way. In all groups, the rats have been laparatomised 72 hours later under general anesthesia and pancreas tissues has been extracted and studied histopathologically. Amylase, lipase, lactate dehydrogenase, aspartate transaminase, alanine tranaminase levels in the rats serum and superoxide dismutase, catalase, glutathione, malondialdehyde, nitricoxide, protein carbonyl, glutathione peroxidase levels in the rats tissue also have been looked up. Results: Serum and tissue findings and histopathologically examination of the pancreas tissues show significant decrease in the treatment group compare to study group. Conclusion: Trimethazidine protects pancreas tissue and decreases the mortality by significantly lowering the biochemical and histopathological changes in the early stages of acute pancreatitis.en_US
dc.identifier.doi10.5152/tjg.2020.18666
dc.identifier.endpage557en_US
dc.identifier.issn2148-5607
dc.identifier.issue8en_US
dc.identifier.pmid32915142en_US
dc.identifier.scopus2-s2.0-85090882055en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage549en_US
dc.identifier.trdizinid412455en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2020.18666
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/412455
dc.identifier.urihttps://hdl.handle.net/11616/92565
dc.identifier.volume31en_US
dc.identifier.wosWOS:000571470300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectna-taurocholateen_US
dc.subjecttrimethazidineen_US
dc.titleThe effect of trimethazidine on mortality in an experimental acute pancreatitis modelen_US
dc.typeArticleen_US

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