The Time in Therapeutic Range and Bleeding Complications of Warfarin in Different Geographic Regions of Turkey: A Subgroup Analysis of WARFARIN-TR Study

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dc.authoridAfsin, Abdulmecit/0000-0001-9301-9525
dc.authoridAskin, Lutfu/0000-0001-7768-2562
dc.authoridSinan, Umit/0000-0002-4837-7099
dc.authoridZoghi, Prof. Dr. Mehdi/0000-0002-8156-2675
dc.authoridözpamuk karadeniz, fatma/0000-0001-5839-9104
dc.authoridÇELİK, AHMET/0000-0002-9417-7610
dc.authoridKış, Mehmet/0000-0003-0775-8992;
dc.authorwosidAfsin, Abdulmecit/JVP-2159-2024
dc.authorwosidAskin, Lutfu/H-1047-2018
dc.authorwosidSinan, Umit/A-7003-2017
dc.authorwosidcelik, Ahmet/IAP-5710-2023
dc.authorwosidZoghi, Prof. Dr. Mehdi/ABB-9550-2020
dc.authorwosidözpamuk karadeniz, fatma/AAC-9156-2022
dc.authorwosidÇELİK, AHMET/AAA-6615-2021
dc.contributor.authorKilic, Salih
dc.contributor.authorCelik, Ahmet
dc.contributor.authorCakmak, Huseyin Altug
dc.contributor.authorAfsin, Abdulmecit
dc.contributor.authorTekkesin, Ahmet Ilker
dc.contributor.authorAciksari, Gonul
dc.contributor.authorMemetoglu, Mehmet Erdem
dc.date.accessioned2024-08-04T20:09:51Z
dc.date.available2024-08-04T20:09:51Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The time in therapeutic range values may vary between different geographical regions of Turkey in patients vitamin K antagonist therapy. Aims: To evaluate the time in therapeutic range percentages, efficacy, safety and awareness of warfarin according to the different geographical regions in patients who participated in the WARFARIN-TR study (The Awareness, Efficacy, Safety and Time in Therapeutic Range of Warfarin in the Turkish population) in Turkey. Study Design: Cross-sectional study. Methods: The WARFARIN-TR study includes 4987 patients using warfarin and involved regular international normalized ratio monitoring between January 1, 2014 and December 31, 2014. Patients attended follow-ups for 12 months. The sample size calculations were analysed according to the density of the regional population and according to Turkish Statistical Institute data. The time in therapeutic range was calculated according to F.R. Roosendaal's algorithm. Awareness was evaluated based on the patients' knowledge of the effect of warfarin and fooddrug interactions with simple questions developed based on a literature review. Results: The Turkey-wide time in therapeutic range was reported as 49.5% +/- 22.9 in the WARFARIN-TR study. There were statistically significant differences between regions in terms of time in therapeutic range (p<0.001). The highest rate was reported in the Marmara region (54.99%+/- 20.91) and the lowest was in the South-eastern Anatolia region (41.95 +/- 24.15) (p< 0.001). Bleeding events were most frequently seen in Eastern Anatolia (41.6%), with major bleeding in the Aegean region (5.11%) and South-eastern Anatolia (5.36%). There were statistically significant differences between the regions in terms of awareness (p< 0.001). Conclusion: Statistically significant differences were observed in terms of the efficacy, safety and awareness of warfarin therapy according to different geographical regions in Turkey.en_US
dc.identifier.doi10.4274/balkanmedj.2016.1617
dc.identifier.endpage355en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid28443575en_US
dc.identifier.scopus2-s2.0-85026922968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage349en_US
dc.identifier.trdizinid260319en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.2016.1617
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/260319
dc.identifier.urihttps://hdl.handle.net/11616/92479
dc.identifier.volume34en_US
dc.identifier.wosWOS:000423237800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWarfarinen_US
dc.subjectawarenessen_US
dc.subjectgeographical differencesen_US
dc.titleThe Time in Therapeutic Range and Bleeding Complications of Warfarin in Different Geographic Regions of Turkey: A Subgroup Analysis of WARFARIN-TR Studyen_US
dc.typeArticleen_US

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