THE INVESTIGATION OF THE ANTIPROLIFERATIVE, ANTIMIGRATION AND ANTIOXIDANT EFFECTS OF TAURINE, CAPSAICIN, MELATONIN AND BETA CAROTEN ON L929 HEALTHY CELLS AND MCF-7 BREAST CANCER CELLS

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dc.authorscopusid57222505412
dc.authorscopusid57211524435
dc.authorscopusid57478631600
dc.authorscopusid26024440900
dc.contributor.authorYüce H.
dc.contributor.authorTürkmen N.B.
dc.contributor.authorÖzek D.A.
dc.contributor.authorÜnüvar S.
dc.date.accessioned2024-08-04T20:03:43Z
dc.date.available2024-08-04T20:03:43Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the antiproliferative, antimigration and antioxidant activities of antioxidant substances such as taurine, capsaicin, melatonin and beta carotene on human breast cancer cells. Material and Method: In this study, taurine, capsaicin, melatonin and beta carotene L929 were applied to healthy fibroblast cells and MCF-7 breast cancer cells. The antiproliferative effect of the compounds was determined by the MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4sulphophenyl)-2H-tetrazolium] test at 24 and 48 hours. Cells were cultured in Dulbecco's Modified Eagles Medium (DMEM) and treated with different concentrations for two consecutive days. The effect of compounds on cell migration was evaluated at 24 hours using the wound healing assay. The wound healing test was used to measure the in vitro metastatic ability of cells. Total antioxidant levels (TAS) and total oxidant levels (TOS) were determined using commercial kits. Result and Discussion: All compounds decreased cell viability in malignant cells in a concentration- and time-dependent manner compared to healthy cells. The results of the wound closure area showed that treatment with the compounds improved cellular migration, which significantly accelerated wound closure. The results showed that all compounds markedly inhibited the migratory ability of MCF-7 cell lines at 48 hours. Although all compounds showed antioxidant effects, beta carotene was observed to have antioxidant effects on MCF-7 cells at almost all doses. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.995491
dc.identifier.endpage61en_US
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125839400en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage48en_US
dc.identifier.trdizinid1111908en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.995491
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1111908
dc.identifier.urihttps://hdl.handle.net/11616/92039
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta caroteneen_US
dc.subjectBreast canceren_US
dc.subjectCapsaicinen_US
dc.subjectMelatoninen_US
dc.subjectTaurineen_US
dc.titleTHE INVESTIGATION OF THE ANTIPROLIFERATIVE, ANTIMIGRATION AND ANTIOXIDANT EFFECTS OF TAURINE, CAPSAICIN, MELATONIN AND BETA CAROTEN ON L929 HEALTHY CELLS AND MCF-7 BREAST CANCER CELLSen_US
dc.title.alternativeTAURİN, KAPSAİSİN, MELATONİN VE BETA KAROTENİN L929 SAĞLIKLI HÜCRELER VE MCF-7 MEME KANSERİ HÜCRELERİ ÜZERİNDEKİ ANTİPROLİFERATİF, ANTİMİGRASYON VE ANTİOKSİDAN ETKİLERİNİN ARAŞTIRILMASIen_US
dc.typeArticleen_US

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