Evaluation of dyslipidemia in preeclamptic pregnant women and determination of the predictive value of the hemato-lipid profile: A prospective, cross- sectional, case-control study

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridözdemir, halis/0000-0002-9194-8504
dc.authoridYASAR, Seyma/0000-0003-1300-3393
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidözdemir, halis/I-5479-2017
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorYasar, Seyma
dc.contributor.authorCelik, Nesibe Zeyveli
dc.contributor.authorOzdemir, Halis
dc.date.accessioned2024-08-04T20:10:10Z
dc.date.available2024-08-04T20:10:10Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: In this study, we examined the serum hematologic and lipid parameters of pregnant women with preeclampsia and an age-and gestational-age matched normotensive control group. We also compared the ratios of hemato-lipid parameters defined as systemic inflammatory markers and determined the predictive value of these values in preeclampsia. Materials and Methods: All patients diagnosed with late-onset preeclampsia or severe preeclampsia between 34 and 40 weeks of gestation at Inonu University Faculty of Medicine between March 2019 and October 2020 were included. Results: A total of 253 pregnant women were included in the study period. When the study groups were compared in terms of hematological and blood lipid profile; while serum lymphocyte, triglyceride, and total cholesterol levels were significantly higher in the preeclampsia group than in the control group (p<0.001, p<0.001, p=0.013, respectively); high-density lipoprotein (HDL)-cholesterol levels were found to be significantly lower (p=0.017). The cut-off value for the monocyte/HDL ratio in predicting severe preeclampsia was 16.65 with 59.0% sensitivity and 85.4% specificity [the area under the receiver operating characteristic 0.756, 95% confidence interval (CI) 0.681-0.821, p<0.001]. Multivariate analysis showed that the monocyte/HDL ratio was independently associated with both preeclampsia and severe preeclampsia [odds ratio (OR): 1.094; 95% CI 1.009-1.185 and OR: 1.731; 95% CI 1.218-2.459, respectively]. Conclusion: This study demonstrated that serum triglyceride and total cholesterol levels were significantly higher and serum HDL-cholesterol levels were significantly lower in pregnant women with late-onset preeclampsia compared to normotensive pregnant women. Additionally, this study revealed that the measurement of monocyte/HDL ratio in the pregnant population could be a useful clinical tool for predicting preeclampsia.en_US
dc.identifier.doi10.4274/tjod.galenos.2022.36744
dc.identifier.endpage20en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue1en_US
dc.identifier.pmid35343215en_US
dc.identifier.scopus2-s2.0-85128473265en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.trdizinid523960en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2022.36744
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/523960
dc.identifier.urihttps://hdl.handle.net/11616/92638
dc.identifier.volume19en_US
dc.identifier.wosWOS:000778573000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDyslipidemiaen_US
dc.subjectpregnancyen_US
dc.subjectHDL cholesterolen_US
dc.subjectmonocytesen_US
dc.subjectpreeclampsiaen_US
dc.titleEvaluation of dyslipidemia in preeclamptic pregnant women and determination of the predictive value of the hemato-lipid profile: A prospective, cross- sectional, case-control studyen_US
dc.typeArticleen_US

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