Anticancer and Antimicrobial Activities of New Cobalt and Zinc Complex-Derived Benzimidazole Containing Nitro or Methyl Groups
Küçük Resim Yok
Tarih
2026
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The cytotoxic effects of six newly synthesized 5(6)-methyl or 5(6)-nitrobenzimidazole-derived compounds that contain cobalt and zinc on nonsmall cell lung carcinoma (A549) and healthy lung epithelial (BEAS-2B) cell lines were evaluated by MTT, caspase-3, and Western Blotting methods. Cisplatin was also used as a reference compound. Compound 4 and compound 5 exhibited high cytotoxic activity against A549. While the IC50 value of cisplatin was 14.31 mu M, IC50 values of compound 4 and compound 5 were 10.30 and 7.01 mu M on A549 cells at 72 h, respectively. On the other hand, for BEAS-2B cells, the IC50 values of cisplatin, compound 4, and compound 5 were 5.91, 90.13, and 51,68 mu M, respectively. The results showed that although compounds 4 and 5 have high cytotoxicity on A549 cells, similar to cisplatin, they are less cytotoxic to BEAS-2B cells than cisplatin. The antibacterial and antifungal properties of the synthesized compounds were also investigated using minimum inhibitory concentration method. Their antimicrobial activities were tested against the Gram-negative bacteria Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853, Gram-positive Staphylococcus aureus ATCC 29213, and yeast species Candida albicans ATCC 90028 and Candida tropicalis. The compounds showed notable antimicrobial activity against these pathogenic bacteria and yeasts.
Açıklama
Anahtar Kelimeler
Metal-Complexes, Apoptosis, Derivatives
Kaynak
Acs Omega
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
11
Sayı
7
