Anticancer and Antimicrobial Activities of New Cobalt and Zinc Complex-Derived Benzimidazole Containing Nitro or Methyl Groups

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dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorApohan, Elif
dc.contributor.authorYesilada, Ozfer
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2026-04-04T13:34:42Z
dc.date.available2026-04-04T13:34:42Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractThe cytotoxic effects of six newly synthesized 5(6)-methyl or 5(6)-nitrobenzimidazole-derived compounds that contain cobalt and zinc on nonsmall cell lung carcinoma (A549) and healthy lung epithelial (BEAS-2B) cell lines were evaluated by MTT, caspase-3, and Western Blotting methods. Cisplatin was also used as a reference compound. Compound 4 and compound 5 exhibited high cytotoxic activity against A549. While the IC50 value of cisplatin was 14.31 mu M, IC50 values of compound 4 and compound 5 were 10.30 and 7.01 mu M on A549 cells at 72 h, respectively. On the other hand, for BEAS-2B cells, the IC50 values of cisplatin, compound 4, and compound 5 were 5.91, 90.13, and 51,68 mu M, respectively. The results showed that although compounds 4 and 5 have high cytotoxicity on A549 cells, similar to cisplatin, they are less cytotoxic to BEAS-2B cells than cisplatin. The antibacterial and antifungal properties of the synthesized compounds were also investigated using minimum inhibitory concentration method. Their antimicrobial activities were tested against the Gram-negative bacteria Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853, Gram-positive Staphylococcus aureus ATCC 29213, and yeast species Candida albicans ATCC 90028 and Candida tropicalis. The compounds showed notable antimicrobial activity against these pathogenic bacteria and yeasts.
dc.description.sponsorshipIn?n? ?niversitesi [1503]
dc.description.sponsorshipThe authors would like to thank the Inonu University Scientific Research Project Unit (Grant No: 1503).
dc.identifier.doi10.1021/acsomega.5c08353
dc.identifier.endpage11327
dc.identifier.issn2470-1343
dc.identifier.issue7
dc.identifier.orcid0000-0003-0038-6575
dc.identifier.orcid0000-0002-7180-9486
dc.identifier.pmid41768623
dc.identifier.scopus2-s2.0-105031004152
dc.identifier.scopusqualityQ1
dc.identifier.startpage11319
dc.identifier.urihttps://doi.org/10.1021/acsomega.5c08353
dc.identifier.urihttps://hdl.handle.net/11616/109355
dc.identifier.volume11
dc.identifier.wosWOS:001685270800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectMetal-Complexes
dc.subjectApoptosis
dc.subjectDerivatives
dc.titleAnticancer and Antimicrobial Activities of New Cobalt and Zinc Complex-Derived Benzimidazole Containing Nitro or Methyl Groups
dc.typeArticle

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