The Effect of Pre-transplant Lipid Profile on Post-transplant Hepatocellular Carcinoma Recurrence: Retrospective Single-Center Analysis

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorInce, Volkan
dc.contributor.authorCarr, Brian, I
dc.contributor.authorUsta, Sertac
dc.contributor.authorErsan, Veysel
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:10:12Z
dc.date.available2024-08-04T20:10:12Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Plasma lipids have been shown to relate to tumor biology. We aimed to analyze the effect of pre-transplant plasma lipid profiles on post-transplant tumor recurrence in patients with hepatocellular carcinoma and to identify any possible relationship between the pre-transplant lipid profile with maximum tumor diameter, number of tumor nodules, tumor differentiation, portal vein invasion, or serum biomarker levels. Methods: Patients with hepatocellular carcinoma who underwent liver transplants between 2006 and 2021 had data collected prospectively and were analyzed retrospectively. Patients who did not have lipid profile data before transplant and whose post-transplant follow-up period was <90 days were excluded. Patients who had pre-transplant plasma lipid data and whose post-transplant follow-up period was >90 days were included in this study (n = 254). Results: Lower high-density lipoprotein cholesterol levels were found to be significantly associated with post-Tx recurrence (38 vs 29.5, P <.001) and were also significantly associated with macroscopic portal vein thrombosis (39 vs 30.4, P <.021). There was no significant association between plasma lipids and tumor differentiation. Higher high-density lipoprotein cholesterol levels were significantly associated with good overall and disease-free survivals (P =.024 and P =.001). Conclusion: Pre-transplant low plasma high-density lipoprotein cholesterol levels were significantly associated with portal vein thrombosis and poor post-transplant overall and disease-free survivals.en_US
dc.identifier.doi10.5152/tjg.2022.21413
dc.identifier.endpage+en_US
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.pmid35678802en_US
dc.identifier.scopus2-s2.0-85131771706en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage434en_US
dc.identifier.trdizinid532793en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2022.21413
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/532793
dc.identifier.urihttps://hdl.handle.net/11616/92653
dc.identifier.volume33en_US
dc.identifier.wosWOS:000865997300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFaten_US
dc.subjectHCCen_US
dc.subjectHDL cholesterolen_US
dc.subjectrelapseen_US
dc.subjecttransplanten_US
dc.subjecttumor thrombosisen_US
dc.titleThe Effect of Pre-transplant Lipid Profile on Post-transplant Hepatocellular Carcinoma Recurrence: Retrospective Single-Center Analysisen_US
dc.typeArticleen_US

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