Assessing lipoxin-mediated inflammatory responses in the second trimester of pregnancy among women with obesity: A comprehensive analysis

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridInceoglu, Feyza/0000-0003-1453-0937
dc.contributor.authorOtlu, Oender
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorInceoglu, Feyza
dc.contributor.authorErenler, Ayse Sebnem
dc.date.accessioned2024-08-04T20:10:23Z
dc.date.available2024-08-04T20:10:23Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to explore the relationship between maternal plasma lipoxin A4 (LXA4) levels during the second trimester of pregnancy and certain proinflammatory molecules, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as well as the antiangiogenic factor vascular endothelial growth factor receptor 1 (VEGFR-1), in conjunction with obesity among pregnant women. Materials and Methods: A total of 30 pregnant women with obesity were compared with 30 pregnant women of normal weight, matched for both age and gestational week. Plasma samples were collected from all participants between the 18th and 28th weeks of pregnancy. The levels of LXA4, VEGFR-1, IL-6, and TNF-alpha were quantified using enzyme-linked immunosorbent assay. Results: Plasma levels of LXA4 were notably lower in pregnant women with obesity, whereas levels of TNF-alpha and VEGFR1 were significantly higher (p=0.041, p<0.001, and p<0.001, respectively). There was no significant difference in IL-6 levels between groups (p=0.072). The binary logistic regression model revealed significant associations between obesity and the examined inflammatory mediators. Specifically, the results demonstrated that higher levels of LXA4 were linked to a reduced obesity risk, with each unit increase corresponding to a 0.926-fold decrease in the likelihood of obesity. Conversely, elevated levels of TNF-alpha and VEGFR1 were associated with an increased risk of obesity. Conclusion: The study concluded that increased body mass index during pregnancy affects the levels of plasma lipoxin, cytokines, and angiogenesis-related factors. Although the exact mechanisms remain unclear, the observed changes suggest a disruption in the metabolic systems of women with obesity, which may influence physiological changes during pregnancy and lead to obesity-related pathological conditions.en_US
dc.identifier.doi10.4274/tjod.galenos.2023.16678
dc.identifier.endpage263en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue4en_US
dc.identifier.pmid38073076en_US
dc.identifier.scopus2-s2.0-85179360079en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage255en_US
dc.identifier.trdizinid1242337en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2023.16678
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1242337
dc.identifier.urihttps://hdl.handle.net/11616/92754
dc.identifier.volume20en_US
dc.identifier.wosWOS:001185971800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiogenic and antiangiogenic factorsen_US
dc.subjectinflammatory mediatorsen_US
dc.subjectlipoxinsen_US
dc.subjectmaternal obesityen_US
dc.subjectpregnancy complicationsen_US
dc.subjectvascular endothelial growth factor receptor 1en_US
dc.titleAssessing lipoxin-mediated inflammatory responses in the second trimester of pregnancy among women with obesity: A comprehensive analysisen_US
dc.typeArticleen_US

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