A2BO4±? as New Materials for Electrocatalytic Detection of Paracetamol and Diclofenac Drugs

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dc.authoridKuyumcu Savan, Ebru/0000-0002-8851-0907
dc.authorwosidKuyumcu Savan, Ebru/E-3430-2019
dc.contributor.authorZine, Amel
dc.contributor.authorFerkhi, Mosbah
dc.contributor.authorKhaled, Ammar
dc.contributor.authorSavan, Ebru Kuyumcu
dc.date.accessioned2024-08-04T20:51:55Z
dc.date.available2024-08-04T20:51:55Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the electrochemical detection of drugs in the human body such as paracetamol and diclofenac was performed using the La2NiO4/carbon black and Pr2NiO4/carbon black electrocatalysts as sensor. The oxide materials were synthesized by the citrate method. The crystallinity of materials was determined by X-ray diffraction; the cell parameters and the crystallite size were calculated using the Debye-Scherrer formula. Morphology and grain size were determined by scanning electron microscope and the pore size was determined by the BET analysis. X-ray photoelectron spectroscopy analysis was used to evaluate the surface state of the synthesized oxide powders. Electrochemical characterization of the drugs on the electrocatalysts was carried out by cyclic voltammetry at different scanning speeds in a range of drug concentrations between 3 and 200 mu mol in a phosphate-buffered saline solution at pH 7. The square wave method was used to determine the detection limits. The synthesized nano-particle-based electrodes demonstrated excellent sensitivity in detecting drug/biomolecules (PCM and DIC) in biological fluids with the minimum detection limit 1.99 mu M and 2.32 mu M, respectively, at La2NiO4/carbon black electrode and 2.04 mu M and 2.37 mu M, respectively, at Pr2NiO4/carbon black electrode. The peak currents relative to the detection of the paracetamol and diclofenac drugs are respectively 800 and 1000 on La2NiO4/carbon black and 1000 and 500 mu A on Pr2NiO4/carbon black. This remarkable behavior enables us to propose these materials as alternative electrocatalysts that act as selective sensors for drug detection in the human body.en_US
dc.identifier.doi10.1007/s12678-022-00745-3
dc.identifier.endpage538en_US
dc.identifier.issn1868-2529
dc.identifier.issn1868-5994
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85129391254en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage524en_US
dc.identifier.urihttps://doi.org/10.1007/s12678-022-00745-3
dc.identifier.urihttps://hdl.handle.net/11616/100631
dc.identifier.volume13en_US
dc.identifier.wosWOS:000791060600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofElectrocatalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSensorsen_US
dc.subjectParacetamol and diclofenac drugsen_US
dc.subjectCyclic voltammetryen_US
dc.subjectLimit detectionen_US
dc.subjectLa2NiO4 and Pr2NiO4 electrocatalystsen_US
dc.titleA2BO4±? as New Materials for Electrocatalytic Detection of Paracetamol and Diclofenac Drugsen_US
dc.typeArticleen_US

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