Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer India
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Backgrounds Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial-mesenchymal transition and tumour invasion. Aims This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC). Methods A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined. Results Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p < 0.05). A tumour size > 2 cm was associated with a poor prognosis. The staining score for fascin-1 was <= 5 in 81 cases and > 5 in 19 cases (p > 0.05), and that for MMP-9 was <= 5 in 39 cases and > 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined. Conclusion There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.
Açıklama
Anahtar Kelimeler
Endometrial carcinoma, Endometrium, Fascin-1, MMP-9, Prognosis
Kaynak
Indian Journal of Gynecologic Oncology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
19
Sayı
1
