Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorTecellioglu, Fahriye Secil
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorSahin, Nurhan
dc.date.accessioned2024-08-04T20:49:17Z
dc.date.available2024-08-04T20:49:17Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgrounds Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial-mesenchymal transition and tumour invasion. Aims This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC). Methods A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined. Results Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p < 0.05). A tumour size > 2 cm was associated with a poor prognosis. The staining score for fascin-1 was <= 5 in 81 cases and > 5 in 19 cases (p > 0.05), and that for MMP-9 was <= 5 in 39 cases and > 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined. Conclusion There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.en_US
dc.identifier.doi10.1007/s40944-020-00492-7
dc.identifier.issn2363-8397
dc.identifier.issn2363-8400
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85100992449en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1007/s40944-020-00492-7
dc.identifier.urihttps://hdl.handle.net/11616/99769
dc.identifier.volume19en_US
dc.identifier.wosWOS:000617130500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Gynecologic Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial carcinomaen_US
dc.subjectEndometriumen_US
dc.subjectFascin-1en_US
dc.subjectMMP-9en_US
dc.subjectPrognosisen_US
dc.titleMmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Valueen_US
dc.typeArticleen_US

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