Prevalence and Features Associated With Restless Leg Syndrome in Postmenopausal Females

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dc.authoridKablan, Yüksel/0000-0002-5581-2968
dc.authorwosidKablan, Yüksel/AAB-5049-2021
dc.contributor.authorUnaldi Karaer, Hatice
dc.contributor.authorKaplan, Yuksel
dc.contributor.authorKurt, Semiha
dc.contributor.authorDemirturk, Fazli
dc.date.accessioned2024-08-04T20:39:51Z
dc.date.available2024-08-04T20:39:51Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Animal and human studies have shown that estrogen modulates dopaminergic activity. The hypoestrogenic state associated with menopause, characterized by a decreased ovarian follicular response to gonadotropins and estrogen, affects the nervous system at multiple anatomical or functional sites. Aims: We investigated the prevalence of restless leg syndrome (RLS) in postmenopausal females and assessed the relationship between RLS and the clinical features of menopause. Methods: We enrolled 523 menopausal females in the study. Of those, 334 (63.86%) did not meet the inclusion criteria and were excluded. Of the remaining 189 postmenopausal patients, 73 met all of the diagnostic criteria for RLS; however, 47 of those had at least one factor related to secondary RLS and were excluded from the study. The remaining 26 (18.3%) postmenopausal patients with idiopathic RLS were categorized as group 1. The control group included 56 postmenopausal females free of RLS and matched by age (+2 years) to group 1. Results: Onset age of menopause was earlier and surgical menopause was more frequent in group 1. The Pearson's correlation test revealed a strong and significant correlation between the onset ages of menopause and RLS. Conclusions: Estrogen receptors are widely distributed throughout the central and peripheral nervous systems. Estrogen modulates dopaminergic activity in the nigrostriatal system. Menopause is characterized by hypoestrogenemia, and may be a risk factor for the development or worsening of RLS symptoms.en_US
dc.identifier.endpage585en_US
dc.identifier.issn1302-1664
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84907272065en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://hdl.handle.net/11616/96557
dc.identifier.volume31en_US
dc.identifier.wosWOS:000347120800014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMenopauseen_US
dc.subjectRestless Legs Syndromeen_US
dc.subjectEstrogenen_US
dc.subjectHypoestrogenemiaen_US
dc.titlePrevalence and Features Associated With Restless Leg Syndrome in Postmenopausal Femalesen_US
dc.typeArticleen_US

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