Diagnostic Value of Bilateral Petrosal Sinus Sampling in Children with Cushing Disease: A Multi-center Study

dc.authoridEr, Eren/0000-0003-4770-0365
dc.authoridDündar, Bumin/0000-0002-7506-061X
dc.authoridTuran, Hande/0000-0003-0121-3756
dc.authorwosidEr, Eren/HNS-7811-2023
dc.authorwosidERCAN, OYA/IUP-6356-2023
dc.authorwosidEvliyaoglu, Olcay/D-6483-2019
dc.authorwosidDündar, Bumin/JVE-1747-2024
dc.contributor.authorTuran, Hande
dc.contributor.authorCatli, Gonul
dc.contributor.authorKardelen, Asli Derya
dc.contributor.authorBober, Ece
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorCetinkaya, Semra
dc.contributor.authorDemirbas, Ozgecan
dc.date.accessioned2024-08-04T20:10:10Z
dc.date.available2024-08-04T20:10:10Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Although the sensitivity and specificity of bilateral inferior petrosal sinus sampling (BIPSS) were shown to be quite high in adult patients, pediatric studies are limited in number and have conflicting results, since BIPSS is much less commonly performed in children. The aim of this study was to assess the role of BIPSS in the detection and accuracy of lateralization of pituitary adenomas in pediatric patients with Cushing disease (CD) and its possible advantage over other diagnostic methods. Methods: This was a multicenter, nationwide, web-based study. The diagnostic value of BIPSS in 16 patients, aged between four and 16.5 years with a confirmed diagnosis of CD, was evaluated retrospectively. The sensitivity and specificity of BIPSS and magnetic resonance imaging (MRI) were calculated, and compared statistically. Results: Standard tests, except for morning cortisol level, were effective in proving the presence of Cushing syndrome. While MRI findings were consistent with microadenoma in eight cases (50%), CD presence and lateralization was successfully predicted in 14 of 16 patients using BIPSS. BIPSS compared with MRI examination was significantly more accurate, both in pre-stimulation and post -stimulation results (p=0.047 and p=0.041, respectively). BIPSS showed a significantly higher sensitivity (92.8%) than MRI in detecting the pituitary source of adrenocorticotropic hormone secretion. Conclusion: These results suggest that BIPSS is superior to MRI for diagnostic work-up to confirm the diagnosis of CD. Moreover, in line with previous studies, BIPSS was shown to provide better information about adenoma location, which is vital for possible surgical intervention.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2021.2021.0152
dc.identifier.endpage36en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue1en_US
dc.identifier.pmid34538049en_US
dc.identifier.scopus2-s2.0-85125683117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage29en_US
dc.identifier.trdizinid515950en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2021.2021.0152
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515950
dc.identifier.urihttps://hdl.handle.net/11616/92630
dc.identifier.volume14en_US
dc.identifier.wosWOS:000778594700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCushing's diseaseen_US
dc.subjectpituitary adenomaen_US
dc.subjectpetrosal sinus samplingen_US
dc.subjectsensitivityen_US
dc.subjectlateralizationen_US
dc.titleDiagnostic Value of Bilateral Petrosal Sinus Sampling in Children with Cushing Disease: A Multi-center Studyen_US
dc.typeArticleen_US

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