Comparative analysis of phytochemical content and antioxidants, anti-cholinesterase, Anti-Atherogenic and molecular docking of Turkish Pelargonium (Pelargonium endlicherianum Fenzl.)
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Pelargonium endlicherianum Fenzl, a perennial shrub in the Geraniaceae family, holds ethnobotanical importance. This study is the first to evaluate the acetylcholinesterase (AChE) and paraoxonase (hPON1) inhibitory activities, alongside the antioxidant properties, of P. endlicherianum extracts. Using LC-MS/MS, 25 phenolic compounds were quantified, with ellagic acid (20,449.65 f 0.60 mg/kg), gallic acid (9,700.31 f 0.03 mg/kg), and fumaric acid (1,691.34 f 33.34 mg/kg) as the dominant bioactive components. Antioxidant assays (DPPH center dot, ABTS center dot+, FRAP, and CUPRAC) demonstrated that the ultrapure water extract exhibited superior activity, with a DPPH center dot scavenging capacity of 75.06 f 0.73% at 0.2 mg/mL. The ultrapure water extract significantly inhibited AChE with an IC50 value of 0.135 f 0.29 mg/mL, while no inhibition of hPON1 was observed, indicating an anti-atherogenic effect. Molecular docking analysis revealed ellagic acid as the most potent compound, with a binding affinity of -10.0 kcal/mol, outperforming the reference inhibitor tacrine (-8.6 kcal/ mol). Gene network analysis supported the involvement of ellagic acid, gallic acid, and fumaric acid in Alzheimer's disease-related pathways. These findings suggest that P. endlicherianum extracts possess significant antioxidant and AChE inhibitory properties, making them promising candidates for therapeutic applications, particularly in neurodegenerative disorders. (c) 2025 SAAB. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Açıklama
Anahtar Kelimeler
Acetylcholinesterase, Antioxidant, LC-MS/MS, Molecular docking, Paraoxonase, Pelargonium endlicherianum
Kaynak
South African Journal of Botany
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
179
