Comparative analysis of phytochemical content and antioxidants, anti-cholinesterase, Anti-Atherogenic and molecular docking of Turkish Pelargonium (Pelargonium endlicherianum Fenzl.)

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dc.contributor.authorGuzel, Abdussamat
dc.contributor.authorUgur, Yilmaz
dc.contributor.authorOner, Erkan
dc.contributor.authorKolac, Turgay
dc.date.accessioned2026-04-04T13:34:50Z
dc.date.available2026-04-04T13:34:50Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractPelargonium endlicherianum Fenzl, a perennial shrub in the Geraniaceae family, holds ethnobotanical importance. This study is the first to evaluate the acetylcholinesterase (AChE) and paraoxonase (hPON1) inhibitory activities, alongside the antioxidant properties, of P. endlicherianum extracts. Using LC-MS/MS, 25 phenolic compounds were quantified, with ellagic acid (20,449.65 f 0.60 mg/kg), gallic acid (9,700.31 f 0.03 mg/kg), and fumaric acid (1,691.34 f 33.34 mg/kg) as the dominant bioactive components. Antioxidant assays (DPPH center dot, ABTS center dot+, FRAP, and CUPRAC) demonstrated that the ultrapure water extract exhibited superior activity, with a DPPH center dot scavenging capacity of 75.06 f 0.73% at 0.2 mg/mL. The ultrapure water extract significantly inhibited AChE with an IC50 value of 0.135 f 0.29 mg/mL, while no inhibition of hPON1 was observed, indicating an anti-atherogenic effect. Molecular docking analysis revealed ellagic acid as the most potent compound, with a binding affinity of -10.0 kcal/mol, outperforming the reference inhibitor tacrine (-8.6 kcal/ mol). Gene network analysis supported the involvement of ellagic acid, gallic acid, and fumaric acid in Alzheimer's disease-related pathways. These findings suggest that P. endlicherianum extracts possess significant antioxidant and AChE inhibitory properties, making them promising candidates for therapeutic applications, particularly in neurodegenerative disorders. (c) 2025 SAAB. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
dc.identifier.doi10.1016/j.sajb.2025.02.017
dc.identifier.endpage133
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.orcid0000-0001-7810-4510
dc.identifier.orcid0000-0002-8462-2493
dc.identifier.orcid0000-0002-9040-4249
dc.identifier.orcid0000-0002-6332-6484
dc.identifier.scopus2-s2.0-85217946554
dc.identifier.scopusqualityQ1
dc.identifier.startpage124
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2025.02.017
dc.identifier.urihttps://hdl.handle.net/11616/109427
dc.identifier.volume179
dc.identifier.wosWOS:001429362800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAcetylcholinesterase
dc.subjectAntioxidant
dc.subjectLC-MS/MS
dc.subjectMolecular docking
dc.subjectParaoxonase
dc.subjectPelargonium endlicherianum
dc.titleComparative analysis of phytochemical content and antioxidants, anti-cholinesterase, Anti-Atherogenic and molecular docking of Turkish Pelargonium (Pelargonium endlicherianum Fenzl.)
dc.typeArticle

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