Sarcopenia and clinical presentation

Basit Öğe Kaydı
dc.contributor.authorErsoy, Yüksel
dc.contributor.authorYıldırım, Tülay
dc.contributor.authorDoğru Gündüz, Hacer
dc.date.accessioned2024-08-04T19:51:54Z
dc.date.available2024-08-04T19:51:54Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSarcopenia is characterized by the progressive generalized loss of muscle function, quality, strength and mass. Although it is known as a primary geriatric disease, it may also develop in younger individuals secondary to immobilization, malnutrion and cachexia. The exact etiology is unknown, but the most commonly suggested contributory factors are a decrease in protein synthesis, mitochondrial dysfunction, reactive oxygen products, chronic inflammation, nutritional deficiency, loss of perfusion, age-related neuromuscular alterations, decrease in sex hormone, growth hormone (GH), insulin-like growth factor (IGF-1) and vitamin D levels together with physical inactivity.There are severe negative effects on quality of life and the individual’s socio-economic status and thus, sarcopenia is a significant public health problem. Sarcopenia is strongly correlated with the increased fragility that develops in the elderly and is a significant risk factor and also an indicator of disability and mortality. The evaluation of muscle strength and physical performance is mandatory for the diagnosis of sarcopenia. Despite the lack of a definitive treatment method, the most commonly accepted approaches include physical activity, nutritional supplementation therapy, and hormonal and new pharmacological agents. In this review sarcopenia, which is a common but sometimes misdiagnosed condition in clinical practice, is discussed in the light of current knowledge.en_US
dc.identifier.doi10.5455/jtomc.2016.02.030
dc.identifier.endpage126en_US
dc.identifier.issn1300-1744
dc.identifier.issue1en_US
dc.identifier.startpage121en_US
dc.identifier.trdizinid284945en_US
dc.identifier.urihttps://doi.org/10.5455/jtomc.2016.02.030
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/284945
dc.identifier.urihttps://hdl.handle.net/11616/89361
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofİnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSarcopenia and clinical presentationen_US
dc.typeReview Articleen_US

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