Increased nitric oxide production in patients with Behcet's disease: Is it a new activity marker?
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mosby, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. The origin of Behcet's disease (BD) is unclear. One of the prominent features of BD is vasculitis and thrombosis as a result of endothelial dysfunction. Because nitric oxide (NO) is synthesized by endothelium, we considered it as an interesting target of investigation in BD. Objective: Our purpose was to define the level of NO in the serum of patients with BD and its relation with disease activity. Methods: As an indicator for NO, serum total nitrite levels (end product of NO) were measured by Griess reaction in 52 consecutive patients with BD and compared with 32 age- and sex-matched healthy staff volunteers. Serum NO levels of active and inactive patients were compared. Results: The overall serum nitrite levels in patients with BD (40.25 +/- 10.51 mumol/L) were significantly higher (P < .001) than those in healthy volunteers (25.09 +/- 5.33 mumol/L). The difference in serum total nitrite levels among patients with active BD (46.74 +/- 10.62 mumol/L) and inactive BD (33.24 +/- 3.73 mumol/L) was significant (P < .001). Significant differences were observed in serum nitrite between patients in the inactive period of BD and the control group (P < .001). Conclusion: Increased NO production might be responsible for the inflammatory process of BD, NO seems to be related to disease activity.
Açıklama
Anahtar Kelimeler
Uveitis, Nitrate
Kaynak
Journal of The American Academy of Dermatology
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
46
Sayı
1
