Increased nitric oxide production in patients with Behcet's disease: Is it a new activity marker?

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorEvereklioglu, C
dc.contributor.authorTurkoz, Y
dc.contributor.authorEr, H
dc.contributor.authorInaloz, HS
dc.contributor.authorOzbek, E
dc.contributor.authorCekmen, M
dc.date.accessioned2024-08-04T20:12:22Z
dc.date.available2024-08-04T20:12:22Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The origin of Behcet's disease (BD) is unclear. One of the prominent features of BD is vasculitis and thrombosis as a result of endothelial dysfunction. Because nitric oxide (NO) is synthesized by endothelium, we considered it as an interesting target of investigation in BD. Objective: Our purpose was to define the level of NO in the serum of patients with BD and its relation with disease activity. Methods: As an indicator for NO, serum total nitrite levels (end product of NO) were measured by Griess reaction in 52 consecutive patients with BD and compared with 32 age- and sex-matched healthy staff volunteers. Serum NO levels of active and inactive patients were compared. Results: The overall serum nitrite levels in patients with BD (40.25 +/- 10.51 mumol/L) were significantly higher (P < .001) than those in healthy volunteers (25.09 +/- 5.33 mumol/L). The difference in serum total nitrite levels among patients with active BD (46.74 +/- 10.62 mumol/L) and inactive BD (33.24 +/- 3.73 mumol/L) was significant (P < .001). Significant differences were observed in serum nitrite between patients in the inactive period of BD and the control group (P < .001). Conclusion: Increased NO production might be responsible for the inflammatory process of BD, NO seems to be related to disease activity.en_US
dc.identifier.doi10.1067/mjd.2002.118338
dc.identifier.endpage54en_US
dc.identifier.issn0190-9622
dc.identifier.issue1en_US
dc.identifier.pmid11756945en_US
dc.identifier.scopus2-s2.0-0036145272en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1067/mjd.2002.118338
dc.identifier.urihttps://hdl.handle.net/11616/93388
dc.identifier.volume46en_US
dc.identifier.wosWOS:000173294800005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby, Incen_US
dc.relation.ispartofJournal of The American Academy of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUveitisen_US
dc.subjectNitrateen_US
dc.titleIncreased nitric oxide production in patients with Behcet's disease: Is it a new activity marker?en_US
dc.typeArticleen_US

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