Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
De Gruyter Poland Sp Z O O
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X-2 (where X = halide) (3a-3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 gmL(-1) and against tyrosinase with an IC50 of 20.77 and 25.84 gmL(-1), respectively. In addition, screening of benzimidazolium salts (2a-2d) and their ruthenium(ii) complexes (3a-3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.
Açıklama
Anahtar Kelimeler
biological activity, benzimidazolium salts, ruthenium complexes, silver complexes, HCT-116, HepG-2
Kaynak
Main Group Metal Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
46
Sayı
1
