Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597;
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.contributor.authorJawhari, Ahmed Hussain
dc.contributor.authorAmri, Nasser
dc.contributor.authorMukhrish, Yousef E.
dc.contributor.authorGatri, Rafik
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorMansour, Lamjed
dc.date.accessioned2024-08-04T20:54:55Z
dc.date.available2024-08-04T20:54:55Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X-2 (where X = halide) (3a-3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 gmL(-1) and against tyrosinase with an IC50 of 20.77 and 25.84 gmL(-1), respectively. In addition, screening of benzimidazolium salts (2a-2d) and their ruthenium(ii) complexes (3a-3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2023R75]en_US
dc.description.sponsorshipThe authors extend their appreciation to the Researchers Supporting Project (number RSP2023R75), King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1515/mgmc-2023-0008
dc.identifier.issn0792-1241
dc.identifier.issn2191-0219
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85179054459en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1515/mgmc-2023-0008
dc.identifier.urihttps://hdl.handle.net/11616/101707
dc.identifier.volume46en_US
dc.identifier.wosWOS:001109537000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofMain Group Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiological activityen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectruthenium complexesen_US
dc.subjectsilver complexesen_US
dc.subjectHCT-116en_US
dc.subjectHepG-2en_US
dc.titleNovel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activitiesen_US
dc.typeArticleen_US

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