The effects of dexmedetomidine on sevoflurane minimum alveolar concentrations
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Dexmedetomidine is an ?2-adrenoreceptor agonist and that reduces the anaesthetic requirement during total intravenous anaesthesia and inhalational anaesthesia. The purpose of this study was to evaluate whether dexmedetomidine administered before anesthesia induction reduces sevoflurane minimum alveolar anaesthetic concentration for endotracheal intubation (MAC EI) and skin incision (MAC). Materials and Methods: Patients were divided into MA-CEI-study and MAC-study subgroup. Both subgroups included 30 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anesthesia and randomly assigned to receive iv saline 0.9% (Group I, n=15 in the each study subgroup) or dexmedetomidine 10 ?g kg-1 bolus + 1 ?g kg-1 h-1 continuous infusion (Group II, n=15 in the each study subgroup). Results: Median and 95% confidence limits for sevoflurane MACEI were 3.06 (2.89-3.25) and 2.69 (2.52-2.84), and for sevoflurane MAC were 2.21 (2.09-2.34) and 1.96 (1.84-2.09) in groups I and II, respectively. There were no significant differences regarding the MACEI and MAC of sevoflurane between groups. Conclusion: We conclude that: dexmedetomidine has no-significant affect on sevoflurane MAC, during endotracheal intubation and skin incision in this group of patients.
Açıklama
Anahtar Kelimeler
Anaesthesia, Dexmedetomidine, Minimum alveolar concentration, Sevoflurane
Kaynak
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
33
Sayı
1
