The effects of dexmedetomidine on sevoflurane minimum alveolar concentrations

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dc.authorscopusid34569135700
dc.authorscopusid8932188900
dc.authorscopusid10739108800
dc.authorscopusid6603402358
dc.authorscopusid7004486274
dc.contributor.authorDurmuş M.
dc.contributor.authorBut A.K.
dc.contributor.authorErdem T.B.
dc.contributor.authorDo?an Z.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:02:07Z
dc.date.available2024-08-04T20:02:07Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Dexmedetomidine is an ?2-adrenoreceptor agonist and that reduces the anaesthetic requirement during total intravenous anaesthesia and inhalational anaesthesia. The purpose of this study was to evaluate whether dexmedetomidine administered before anesthesia induction reduces sevoflurane minimum alveolar anaesthetic concentration for endotracheal intubation (MAC EI) and skin incision (MAC). Materials and Methods: Patients were divided into MA-CEI-study and MAC-study subgroup. Both subgroups included 30 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anesthesia and randomly assigned to receive iv saline 0.9% (Group I, n=15 in the each study subgroup) or dexmedetomidine 10 ?g kg-1 bolus + 1 ?g kg-1 h-1 continuous infusion (Group II, n=15 in the each study subgroup). Results: Median and 95% confidence limits for sevoflurane MACEI were 3.06 (2.89-3.25) and 2.69 (2.52-2.84), and for sevoflurane MAC were 2.21 (2.09-2.34) and 1.96 (1.84-2.09) in groups I and II, respectively. There were no significant differences regarding the MACEI and MAC of sevoflurane between groups. Conclusion: We conclude that: dexmedetomidine has no-significant affect on sevoflurane MAC, during endotracheal intubation and skin incision in this group of patients.en_US
dc.identifier.endpage47en_US
dc.identifier.issn1304-0871
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-14844282300en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/11616/91438
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnaesthesiaen_US
dc.subjectDexmedetomidineen_US
dc.subjectMinimum alveolar concentrationen_US
dc.subjectSevofluraneen_US
dc.titleThe effects of dexmedetomidine on sevoflurane minimum alveolar concentrationsen_US
dc.title.alternativeDeksmedetomidinin sevofluran minimum alveolar anestezik konsantrasyonlarina etkisien_US
dc.typeArticleen_US

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