PREDICTIVE BIOMARKERS OF LIVING DONOR LIVER TRANSPLANTATION

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dc.authorscopusid58648695700
dc.authorscopusid17435600600
dc.authorscopusid57222505412
dc.authorscopusid7102264810
dc.authorscopusid57211524435
dc.authorscopusid57195636045
dc.authorscopusid6603745283
dc.contributor.authorÇiftçi Ö.F.
dc.contributor.authorŞahin T.T.
dc.contributor.authorYüce H.
dc.contributor.authorYilmaz S.
dc.contributor.authorTürkmen N.B.
dc.contributor.authorYaşar Ş.
dc.contributor.authorÇoban T.
dc.date.accessioned2024-08-04T20:03:45Z
dc.date.available2024-08-04T20:03:45Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Liver transplantation using a living donor (LDLT) is currently the most popular method used in the worldwide. Appropriate biomarkers that predict graft status should be used to detect early post-transplant complications that may lead to a rejection reaction. Material and Method: The study involved a total of 44 liver recipients and 44 liver donors, from whom preoperative blood samples were taken and immunoassay and spectrophotometric studies were carried out. The levels of serum neopterin, interferon-gamma (IFN- y), indoleamine-2,3 dioxygenase (IDO), and -glutathione S transferase (a-GST) were assessed using an enzyme-linked immunosorbent test. The activity of glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD) in erythrocytes was measured using spectrophotometry. Result and Discussion: "Neopterin, IDO, and G6PD levels were significantly higher in the recipient group than in the donor group. The differences in gender and blood groups were statistically insignificant. The rejection reaction developed in 25% of patients and none survived. These findings may facilitate the identification of novel predictive biomarkers for the diagnosis of acute rejection reactions after LDLT. The clinical use of novel non-invasive biomarkers may provide time and cost advantages. © 2023 University of Ankara. All rights reserved.en_US
dc.description.sponsorshipTDK-2019-1641en_US
dc.description.sponsorshipThe Department of Scientific Research Projects at İnönü University provided funding for present study (Project number: TDK-2019-1641).en_US
dc.identifier.doi10.33483/jfpau.1247781
dc.identifier.endpage966en_US
dc.identifier.issn2564-6524
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85174146055en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage957en_US
dc.identifier.trdizinid1197150en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1247781
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1197150
dc.identifier.urihttps://hdl.handle.net/11616/92046
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectG6PDen_US
dc.subjectIFN-?en_US
dc.subjectindoleamine-2,3-dioxygenaseen_US
dc.subject?-GST liver transplantationen_US
dc.titlePREDICTIVE BIOMARKERS OF LIVING DONOR LIVER TRANSPLANTATIONen_US
dc.typeArticleen_US

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