Development of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndrome

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dc.contributor.authorGulubova, Maya
dc.contributor.authorTolekova, Anna
dc.contributor.authorBerbatov, Dimitar
dc.contributor.authorAydogdu, Nurettin
dc.date.accessioned2024-08-04T20:54:39Z
dc.date.available2024-08-04T20:54:39Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractContextThere is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats.ObjectiveWe evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres.Materials and methodsWistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples were elaborated with immunohistochemistry for Insulin, Glucagon, Ghrelin, and Somatostatin. Glucose and lipid parameters were studied.ResultsIn treated animals, Ghrelin+ and Insulin+ cells in perybiliary glands (PBGs) were significantly increased. In the male fructose group there was a significant increase of the homeostasis model assessment insulin resistance (HOMA-IR).ConclusionsStem/progenitor cells in extrahepatic bile tree (EHBT) could be a source of Insulin-producing cells in metabolic syndrome. Fructose treatment induces the increase of Ghrelin+ and Insulin+ cells in PBGs and the elevation of Insulin and Ghrelin plasma concentration.en_US
dc.description.sponsorshipBulgarian Ministry of Education and Science [577/17.08.2018]en_US
dc.description.sponsorshipThis work was supported by the Bulgarian Ministry of Education and Science under the National Research Programme Healthy Foods for a Strong Bio-Economy and Quality of Life approved by DCM [# 577/17.08.2018] and National Scientific Programme for support of young scientists and post-doctoral scientists administered by the Ministry of Education and Science, Bulgaria with decision No. [577/17.08.2018]en_US
dc.identifier.doi10.1080/13813455.2023.2252205
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.pmid37651586en_US
dc.identifier.scopus2-s2.0-85169313003en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2023.2252205
dc.identifier.urihttps://hdl.handle.net/11616/101552
dc.identifier.wosWOS:001062443000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectinsulinen_US
dc.subjectglucagonen_US
dc.subjectsomatostatinen_US
dc.subjectperibiliary glandsen_US
dc.titleDevelopment of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndromeen_US
dc.typeArticleen_US

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