Effect of nitric oxide on bacterial translocation in experimental intestinal obstruction

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dc.authorscopusid7003344837
dc.authorscopusid6503897108
dc.authorscopusid55903323700
dc.authorscopusid6603062857
dc.authorscopusid6602248295
dc.authorscopusid35570759500
dc.authorscopusid6602807812
dc.contributor.authorHasano?lu A.
dc.contributor.authorKaradaş K.
dc.contributor.authorTürköz Y.
dc.contributor.authorÖzerol I.H.
dc.contributor.authorTekereko?lu M.S.
dc.contributor.authorAydin N.E.
dc.contributor.authorErtaş E.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBacterial translocation is defined as the passage of endogenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs that suggested to be the cause of sepsis in patient with multiple organ failure. The aim of this study was to investigate the antibacterial effect of nitric oxide by using nitric oxide synthetase enzyme inhibitors such as L-NAME and aminoguanidin in the obstructive intestinal rat model. Fourty rats were divided into four groups. The first one was control group and had only laparatomy. Intestinal obstruction was performed to second group, intestinal obstruction + L-NAME (L-NG-nitro-L-arginine methyl ester) were applied to third group. Fourth group had intestinal obstruction and aminoguanidin was injected to them. According to the histopathological study of the intestine, group III demonstrated less ulceration than groups II and IV (p<0.05). Mucosal damage and bacterial translocation showed no correlation according to the results. The incidence of bacterial translocation was 46.6% in group II, 73.3% in group III and 90% in group IV. Eighty two percent of isolated bacteria was typical enteric Gram negative organisms. Bacterial translocation was not observed in control group. Plasma nitric oxide levels of groups were 14.0±3.3, 31.2±7.6, 12.2±2.5, and 10.5±1.8 ?mol/L, respectively. As a conclusion; nitric oxide can damage mucosal integrity that may increase bacterial translocation but the antibacterial effect of nitric oxide may be more effective and nitric oxide can decrease the translocation of bacteria from gut.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1300-0705
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0035708324en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/11616/91162
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Surgical Societyen_US
dc.relation.ispartofTurkish Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial translocationen_US
dc.subjectIntestinal obstructionen_US
dc.subjectNitric oxideen_US
dc.titleEffect of nitric oxide on bacterial translocation in experimental intestinal obstructionen_US
dc.title.alternativeDeneysel barsak obstrüksiyonunda nitrik oksitin bakteriyel translokasyona etkisien_US
dc.typeArticleen_US

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