Synthesis, antioxidant and carbonic anhydrase inhibitory properties of monopeptide-anthraquinone conjugates

Basit Öğe Kaydı
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridBartolucci, Gianluca/0000-0002-5631-8769
dc.authoridSupuran, Claudiu/0000-0003-4262-0323
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorParladi, F. Muzeyyen
dc.contributor.authorKucukbay, F. Zehra
dc.contributor.authorAngeli, Andrea
dc.contributor.authorBartolucci, Gianluca
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2024-08-04T20:10:09Z
dc.date.available2024-08-04T20:10:09Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNovel monopeptide-anthraquinone conjugates (1-16) were synthesized by the reaction of appropriate N-protected amino acid with 2-hydroxymethylanthraquinone in good or high yields. The structural elucidation of the new compounds was accomplished by H-1 NMR, C-13 NMR, MS, FT-IR spectroscopy and elemental analysis techniques. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of the new compounds was determined against two human (h) isoforms, hCA I and hCA II. While three of the sixteen compounds showed moderate in vitro carbonic anhydrase inhibitory properties against hCA II with inhibition constants in the micromolar level (43.5, 67.4 and 78.1 mu M), they did not show inhibitory activity against hCA I up to 100 mu M concentration. The antioxidant abilities of the compounds were determined using the 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging method, ferric ion reducing assay and metal chelation methods. While a small amount of antioxidant activity was observed according to the DPPH and ferric ion reducing power assay methods, none of the compounds showed antioxidant properties according to the metal chelating activity method at the concentrations studied.en_US
dc.description.sponsorshipInonu University Research Fund [FYL-2019-1634]en_US
dc.description.sponsorshipThis work was financially supported by the Inonu University Research Fund (FYL-2019-1634).en_US
dc.identifier.doi10.25135/acg.oc.108.2107.2126
dc.identifier.endpage269en_US
dc.identifier.issn1307-6175
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85115817603en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage255en_US
dc.identifier.trdizinid515661en_US
dc.identifier.urihttps://doi.org/10.25135/acg.oc.108.2107.2126
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515661
dc.identifier.urihttps://hdl.handle.net/11616/92611
dc.identifier.volume14en_US
dc.identifier.wosWOS:000698007000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofOrganic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnthraquinone derivativesen_US
dc.subjectmonopeptide anthraquinone conjugatesen_US
dc.subjectcarbonic anhydrase inhibitionen_US
dc.subjectantioxidant activityen_US
dc.titleSynthesis, antioxidant and carbonic anhydrase inhibitory properties of monopeptide-anthraquinone conjugatesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu