Anti-Cancer and Antimicrobial Properties of St. John's Wort (Hypericum perforatum)

Basit Öğe Kaydı
dc.contributor.authorKarci, Hüseyin
dc.date.accessioned2026-04-04T13:19:06Z
dc.date.available2026-04-04T13:19:06Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractSt. John's Wort (Hypericum perforatum) is a medicinal plant widely used in traditional medicine, known for its significant pharmacological properties, including antimicrobial and antitumor activities. In this study, extracts of Hypericum perforatum were prepared using the maceration method from plants collected at the foothills of Kubbe Mountain, located in the Pütürge district of Malatya province. These extracts were evaluated for their antimicrobial and anticancer activities. Antimicrobial activity was investigated against microorganisms, including Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Pseudomonas aeruginosa (ATCC 27853), Candida albicans (SC5314/ATCC MYA-2876), and Candida glabrata (ATCC 2001), using the Disk Diffusion Test. Anticancer activity was assessed in HCT116 (human colon cancer), SH-SY5Y (human brain cancer), and BEAS-2B (human healthy lung cell) lines using the MTT assay, with IC50 values compared to those of the standard anticancer drug, Cisplatin. Regarding antimicrobial activity, the inhibition zones were measured as 9.33±0.78 mm for E. coli, 12.17±0.53 mm for P. aeruginosa, and 11.73±0.41 mm for S. aureus. No inhibition was observed for the yeasts C. albicans and C. glabrata. Low cytotoxicity was observed in the healthy cell line BEAS-2B, with an IC50 value of 48.87 ± 7.03 μg/mL, whereas high cytotoxicity was detected in cancer cell lines, with IC50 values of 23.27±3.35 μg/mL for SH-SY5Y and 10.67±3.05 μg/mL for HCT116. These findings indicate that Hypericum perforatum extract can effectively target cancer cells while sparing healthy cells, suggesting its potential for selective toxicity. In conclusion, Hypericum perforatum extract demonstrated significant antimicrobial activity against P. aeruginosa and S. aureus, as well as strong cytotoxicity in cancer cell lines, highlighting its potential as a natural therapeutic agent. © 2025, Inonu University. All rights reserved.
dc.identifier.doi10.33715/inonusaglik.1544916
dc.identifier.endpage191
dc.identifier.issn2147-7892
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105000867400
dc.identifier.scopusqualityQ4
dc.identifier.startpage181
dc.identifier.trdizinid1301703
dc.identifier.urihttps://doi.org/10.33715/inonusaglik.1544916
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1301703
dc.identifier.urihttps://hdl.handle.net/11616/108163
dc.identifier.volume13
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKarci, Hüseyin
dc.language.isotr
dc.publisherInonu University
dc.relation.ispartofJournal of Inonu University Vocational School of Health Services
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectAnticancer
dc.subjectAntimicrobial
dc.subjectDisk diffusion test
dc.subjectMTT
dc.subjectSt. John's wort
dc.titleAnti-Cancer and Antimicrobial Properties of St. John's Wort (Hypericum perforatum)
dc.title.alternativeSARI KANTARON (Hypericum perforatum) BİTKİSİNİN ANTİKANSER VE ANTİMİKROBİYAL ÖZELLİKLERİ]
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu