The pathological examinations of gastric mucosa in patients with Helicobacter pylori-positive and -negative pernicious anemia
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. The basic histopathological finding in gastric mucosa is chronic atrophic gastritis in patients with pernicious anemia. Materials and Methods. We evaluated the frequency of Helicobacter pylori and pathological examinations of gastric mucosa in pernicious anemia (n = 30) by endoscopical findings and biopsy. The results were compared with gastric mucosa specimens of patients with H. pylori-positive nonulcer dyspepsia (n = 36) and H. pylori-negative nonulcer dyspepsia (n = 21). Results. H. pylori was diagnosed in 12 patients (40%) with pernicious anemia. Fundal biopsy examinations showed atrophic gastritis in 30 patients (100%), intestinal metaplasia in 13 patients (43.3%), lymphoid follicle in 15 patients (50%), and dysplasia in 6 patients (20%). Antral biopsy examinations showed atrophic gastritis in 8 patients (26.6%), intestinal metaplasia in 8 patients (26.6%), lymphoid follicle in 8 patients (26.6%), and dysplasia in 3 patients (10%). The frequency of fundal inflammation, atrophy, intestinal metaplasia, lymphoid follicle, and dysplasia and antral intestinal metaplasia and mild antral dysplasia were found to be higher in those in the pernicious anemia group than in the nonulcer dyspeptic patients. Antral inflammation, atrophy, and moderate and severe antral dysplasia were found to be higher in chose in the nonulcer dyspeptic group. Conclusions. Particularly, fundal precancerous lesions were found to be more frequent in patients with pernicious anemia independent of H. pylori.
Açıklama
Anahtar Kelimeler
Lymphoid Follicles, Intestinal Metaplasia, Atrophic Gastritis, Carcinoid-Tumors, High Prevalence, Follow-Up, Infection, Stomach, Subpopulations, Population
Kaynak
Helicobacter
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
5
Sayı
4
