The pathological examinations of gastric mucosa in patients with Helicobacter pylori-positive and -negative pernicious anemia

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dc.authoridSevinç, Alper/0000-0002-0499-8918;
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidSari, Ramazan/C-2868-2016
dc.contributor.authorSari, R
dc.contributor.authorOzen, S
dc.contributor.authorAydogdu, I
dc.contributor.authorYildirim, B
dc.contributor.authorSevinc, A
dc.date.accessioned2024-08-04T20:12:11Z
dc.date.available2024-08-04T20:12:11Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The basic histopathological finding in gastric mucosa is chronic atrophic gastritis in patients with pernicious anemia. Materials and Methods. We evaluated the frequency of Helicobacter pylori and pathological examinations of gastric mucosa in pernicious anemia (n = 30) by endoscopical findings and biopsy. The results were compared with gastric mucosa specimens of patients with H. pylori-positive nonulcer dyspepsia (n = 36) and H. pylori-negative nonulcer dyspepsia (n = 21). Results. H. pylori was diagnosed in 12 patients (40%) with pernicious anemia. Fundal biopsy examinations showed atrophic gastritis in 30 patients (100%), intestinal metaplasia in 13 patients (43.3%), lymphoid follicle in 15 patients (50%), and dysplasia in 6 patients (20%). Antral biopsy examinations showed atrophic gastritis in 8 patients (26.6%), intestinal metaplasia in 8 patients (26.6%), lymphoid follicle in 8 patients (26.6%), and dysplasia in 3 patients (10%). The frequency of fundal inflammation, atrophy, intestinal metaplasia, lymphoid follicle, and dysplasia and antral intestinal metaplasia and mild antral dysplasia were found to be higher in those in the pernicious anemia group than in the nonulcer dyspeptic patients. Antral inflammation, atrophy, and moderate and severe antral dysplasia were found to be higher in chose in the nonulcer dyspeptic group. Conclusions. Particularly, fundal precancerous lesions were found to be more frequent in patients with pernicious anemia independent of H. pylori.en_US
dc.identifier.doi10.1046/j.1523-5378.2000.00033.x
dc.identifier.endpage221en_US
dc.identifier.issn1083-4389
dc.identifier.issue4en_US
dc.identifier.pmid11179986en_US
dc.identifier.scopus2-s2.0-0034583809en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1046/j.1523-5378.2000.00033.x
dc.identifier.urihttps://hdl.handle.net/11616/93275
dc.identifier.volume5en_US
dc.identifier.wosWOS:000166399700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Science Incen_US
dc.relation.ispartofHelicobacteren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphoid Folliclesen_US
dc.subjectIntestinal Metaplasiaen_US
dc.subjectAtrophic Gastritisen_US
dc.subjectCarcinoid-Tumorsen_US
dc.subjectHigh Prevalenceen_US
dc.subjectFollow-Upen_US
dc.subjectInfectionen_US
dc.subjectStomachen_US
dc.subjectSubpopulationsen_US
dc.subjectPopulationen_US
dc.titleThe pathological examinations of gastric mucosa in patients with Helicobacter pylori-positive and -negative pernicious anemiaen_US
dc.typeArticleen_US

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