Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism

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dc.authoridOzbas, Serdar/0000-0002-8019-8015
dc.authoridDeveci, Ugur/0000-0003-4449-1190
dc.authoridErel, Serap/0000-0001-7365-883X
dc.authoridEmre, Ali Ugur/0000-0002-1136-0517
dc.authoridCAKMAK, Guldeniz KARADENIZ/0000-0001-5802-4441;
dc.authorwosidCanturk, Nuh Zafer/AAS-3915-2020
dc.authorwosidOzbas, Serdar/ABI-5204-2020
dc.authorwosidArici, Cumhur/C-7103-2016
dc.authorwosidÖzçınar, Beyza/HJH-3411-2023
dc.authorwosidDeveci, Ugur/JWO-9218-2024
dc.authorwosidErel, Serap/AAI-2387-2019
dc.authorwosidEmre, Ali Ugur/JWA-0250-2024
dc.contributor.authorMakay, Ozer
dc.contributor.authorOzcinar, Beyza
dc.contributor.authorSimsek, Turgay
dc.contributor.authorArici, Cumhur
dc.contributor.authorGungor, Bulent
dc.contributor.authorOzbas, Serdar
dc.contributor.authorAkca, Tamer
dc.date.accessioned2024-08-04T20:09:50Z
dc.date.available2024-08-04T20:09:50Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. Aims: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. Study Design: Retrospective, clinical-based multicentric study of 694 patients with pHPT. Methods: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. Results: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. Conclusion: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT.en_US
dc.identifier.doi10.4274/balkanmedj.2015.0865
dc.identifier.endpage34en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid28251020en_US
dc.identifier.scopus2-s2.0-85013819579en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage28en_US
dc.identifier.trdizinid240487en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.2015.0865
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/240487
dc.identifier.urihttps://hdl.handle.net/11616/92469
dc.identifier.volume34en_US
dc.identifier.wosWOS:000396361900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperparathyroidismen_US
dc.subjectclinocopathological featuresen_US
dc.subjectregional differencesen_US
dc.subjectTurkeyen_US
dc.subjectBulgariaen_US
dc.titleRegional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidismen_US
dc.typeArticleen_US

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