Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were studied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA<BCC<AK<SCC<SK (p<0.005), BCC<KA<SK<SCC<AK (p<0.05), AK<KA<BCC<SCC<SK (p<0.05). p21 expression was more prominent in premalignant (AK) lesions compared with malignant (BCC, SCC) ones (p<0.05). Conclusions: Our results suggest that HPV does not have a direct role in the aetiology of benign, premalignant and malignant lesions. Proliferation markers should be evaluated along with hematoxylen&eosin stained specimens for distinguishing benign, premalignant and malignant lesions. Prospective studies are still needed in this field.
Açıklama
Anahtar Kelimeler
bcl-2, Human papilloma virus, Ki-67, p21
Kaynak
Turkderm Deri Hastaliklari ve Frengi Arsivi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
41
Sayı
2
