Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation

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dc.authorscopusid10141031200
dc.authorscopusid36876295100
dc.authorscopusid6602612326
dc.authorscopusid6603392601
dc.authorscopusid57195695569
dc.contributor.authorSerarslan G.
dc.contributor.authorAtik E.
dc.contributor.authorOtlu B.
dc.contributor.authorBakariş S.
dc.contributor.authorDurmaz R.
dc.date.accessioned2024-08-04T20:00:40Z
dc.date.available2024-08-04T20:00:40Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were studied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA<BCC<AK<SCC<SK (p<0.005), BCC<KA<SK<SCC<AK (p<0.05), AK<KA<BCC<SCC<SK (p<0.05). p21 expression was more prominent in premalignant (AK) lesions compared with malignant (BCC, SCC) ones (p<0.05). Conclusions: Our results suggest that HPV does not have a direct role in the aetiology of benign, premalignant and malignant lesions. Proliferation markers should be evaluated along with hematoxylen&eosin stained specimens for distinguishing benign, premalignant and malignant lesions. Prospective studies are still needed in this field.en_US
dc.identifier.endpage62en_US
dc.identifier.issn1019-214X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34547764337en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://hdl.handle.net/11616/90919
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkderm Deri Hastaliklari ve Frengi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbcl-2en_US
dc.subjectHuman papilloma virusen_US
dc.subjectKi-67en_US
dc.subjectp21en_US
dc.titleExpression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolationen_US
dc.title.alternativeBenin, premalin ve malin lezyonlarda hücre proliferasyon belirleyicilerinin ekspresyonu ve i?nsan papilloma virus i?zolasyonuen_US
dc.typeArticleen_US

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